L
Lisa H F McGary
Researcher at University of California, San Francisco
Publications - 4
Citations - 271
Lisa H F McGary is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Quizartinib & Neuroblastoma RAS viral oncogene homolog. The author has an hindex of 1, co-authored 3 publications receiving 144 citations.
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Journal ArticleDOI
Clonal Selection with RAS Pathway Activation Mediates Secondary Clinical Resistance to Selective FLT3 Inhibition in Acute Myeloid Leukemia
Christine M. McMahon,Timothy T. Ferng,Jonathan Canaani,Eunice S. Wang,Jennifer J.D. Morrissette,Dennis J. Eastburn,Maurizio Pellegrino,Robert Durruthy-Durruthy,Christopher D. Watt,Saurabh Asthana,Elisabeth A. Lasater,Elisabeth A. Lasater,Rosa Anna DeFilippis,Cheryl A.C. Peretz,Lisa H F McGary,Safoora Deihimi,Aaron C Logan,Selina M. Luger,Neil P. Shah,Martin Carroll,Catherine C. Smith,Alexander E. Perl +21 more
TL;DR: Dynamic and complex changes in clonal architecture underlying response and resistance to mutation-selective tyrosine kinase inhibitor therapy in AML are illustrated.
Journal ArticleDOI
Single-cell DNA sequencing reveals complex mechanisms of resistance to quizartinib.
Cheryl A.C. Peretz,Cheryl A.C. Peretz,Lisa H F McGary,Tanya F Kumar,Hunter Jackson,Jose Jacob,Robert Durruthy-Durruthy,Mark Levis,Alexander E. Perl,Benjamin J. Huang,Catherine C. Smith +10 more
TL;DR: In this article, single-cell sequencing exposes previously unmeasurable complexity of tumor heterogeneity and clonal evolution on quizartinib and reveals on-and off-target mechanisms of resistance to quizartrinib, which can preexist therapy.
Journal ArticleDOI
Single Cell Sequencing Reveals Evolution of Tumor Heterogeneity of Acute Myeloid Leukemia on Quizartinib
Cheryl A.C. Peretz,Cheryl A.C. Peretz,Lisa H F McGary,Tanya F Kumar,J. Hunter Jackson,Jose Jacob,Robert Durruthy-Durruthy,Chunxiao Zhang,Mark J. Levis,Alexander E. Perl,Anskar Y.H. Leung,Catherine C. Smith +11 more
TL;DR: Single cell (SC) sequencing allows for direct measurement of clonality, co-mutational status, zygosity, and clonal evolution, and reveals that individual mutations may be present in a number of different combinations and confirms that polyclonality is common within a single leukemia.
letters-and-commentsDOI
Vive la Résistance: T-cell Immunity in the Protection against SARS-CoV-2 Infection.
Lisa H F McGary,Santosh Vardhana +1 more
TL;DR: The results of this study suggest that a cellular response against the Spike 1 protein receptor binding domain (S1-RBD) region of the SARS-CoV-2 proteome contributes to protection and that mutations in this region may drive viral evolution and immune escape.