M
Maurizio Pellegrino
Researcher at University of California, Berkeley
Publications - 15
Citations - 1808
Maurizio Pellegrino is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: DNA sequencing & Myeloid leukemia. The author has an hindex of 9, co-authored 15 publications receiving 1361 citations.
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Journal ArticleDOI
The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch
Sarah R. Wilson,Sarah R. Wilson,Lyn Batia,Katherine Beattie,George E. Katibah,Shannan P. McClain,Maurizio Pellegrino,Daniel Estandian,Diana M. Bautista,Diana M. Bautista +9 more
TL;DR: The results support a model whereby calcium-dependent TSLP release by keratinocytes activates both primary afferent neurons and immune cells to promote inflammatory responses in the skin and airways.
Journal ArticleDOI
TRPA1: A Gatekeeper for Inflammation
TL;DR: Tissue damage evokes an inflammatory response that promotes the removal of harmful stimuli, tissue repair, and protective behaviors to prevent further damage and encourage healing, making TRPA1 a gatekeeper of chronic inflammatory disorders of the skin, airways, and gastrointestinal tract.
Journal ArticleDOI
Clonal Selection with RAS Pathway Activation Mediates Secondary Clinical Resistance to Selective FLT3 Inhibition in Acute Myeloid Leukemia
Christine M. McMahon,Timothy T. Ferng,Jonathan Canaani,Eunice S. Wang,Jennifer J.D. Morrissette,Dennis J. Eastburn,Maurizio Pellegrino,Robert Durruthy-Durruthy,Christopher D. Watt,Saurabh Asthana,Elisabeth A. Lasater,Elisabeth A. Lasater,Rosa Anna DeFilippis,Cheryl A.C. Peretz,Lisa H F McGary,Safoora Deihimi,Aaron C Logan,Selina M. Luger,Neil P. Shah,Martin Carroll,Catherine C. Smith,Alexander E. Perl +21 more
TL;DR: Dynamic and complex changes in clonal architecture underlying response and resistance to mutation-selective tyrosine kinase inhibitor therapy in AML are illustrated.
Journal ArticleDOI
High-throughput single-cell DNA sequencing of acute myeloid leukemia tumors with droplet microfluidics.
Maurizio Pellegrino,Adam Sciambi,Sebastian Treusch,Robert Durruthy-Durruthy,Kaustubh Gokhale,Jose Jacob,Tina X. Chen,Jennifer A. Geis,William M. Oldham,Jairo Matthews,Hagop M. Kantarjian,P. Andrew Futreal,Keyur P. Patel,Keith W. Jones,Koichi Takahashi,Dennis J. Eastburn +15 more
TL;DR: A novel microfluidic approach that barcodes amplified genomic DNA from thousands of individual cancer cells confined to droplets will make feasible the routine analysis of AML heterogeneity, leading to improved stratification and therapy selection for the disease.
Journal ArticleDOI
HTR7 mediates serotonergic acute and chronic itch
Takeshi Morita,Takeshi Morita,Shannan P. McClain,Lyn Batia,Maurizio Pellegrino,Sarah R. Wilson,Sarah R. Wilson,Michael A. Kienzler,Kyle A. Lyman,Anne Sofie Braun Olsen,Justin F. Wong,Cheryl L. Stucky,Rachel B. Brem,Rachel B. Brem,Diana M. Bautista,Diana M. Bautista +15 more
TL;DR: A role for HTR7 in acute and chronic itch is highlighted and it is suggested that H TR7 antagonists may be useful for treating a variety of pathological itch conditions.