L
Lisa M. Coussens
Researcher at Oregon Health & Science University
Publications - 266
Citations - 71080
Lisa M. Coussens is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Immune system & Cancer. The author has an hindex of 88, co-authored 232 publications receiving 60476 citations. Previous affiliations of Lisa M. Coussens include Genentech & Icahn School of Medicine at Mount Sinai.
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Journal ArticleDOI
Poker face no more: cancer recurrence reveals its hand.
TL;DR: A new study suggests that an inflammatory cytokine signature may provide a clinical indication of emergent recurrent disease and, accordingly, may suggest how to select and deliver therapy targeted against the secondary tumor.
Proceedings ArticleDOI
Abstract 3296: SMMART: Serial measurements of molecular and architectural responses to therapy
Brett Johnson,Jamie M. Keck,Max Morris,Kiara Siex,Annette Kolodzie,Swapnil Parmar,Jessica L. Riesterer,Koei Chin,Summer L. Gibbs,Laura M. Heiser,Paul T. Spellman,Kyle Ellrott,Özgün Babur,Emek Demir,Adam A. Margolin,Jeremy Goecks,Lisa M. Coussens,Raymond C. Bergan,Joe W. Gray +18 more
TL;DR: The integrative analyses of multiple data types provided insight into the evolution of actionable biology within this patient9s disease, including changes in the suitability of the patient for immune checkpoint inhibitors as well as specific tyrosine kinase inhibitors.
Journal ArticleDOI
Deciphering the Immune Complexity in Esophageal Adenocarcinoma and Pre-Cancerous Lesions With Sequential Multiplex Immunohistochemistry and Sparse Subspace Clustering Approach
S. Sundaram,Eun Na Kim,G M Jones,Shamilene Sivagnanam,Monika Tripathi,Ahmad Miremadi,Massimiliano di Pietro,Lisa M. Coussens,Rebecca C. Fitzgerald,Young Hwan Chang,Lizhe Zhuang +10 more
TL;DR: This study revealed immune dynamics in EAC progression and highlighted the potential application of a new multiplex imaging platform, combined with computational image analysis on routine clinical FFPE sections, to investigate complex immune populations in tumor ecosystems.
Posted ContentDOI
An Omic and Multidimensional Spatial Atlas from Serial Biopsies of an Evolving Metastatic Breast Cancer
Brett Johnson,Allison L. Creason,Jayne M. Stommel,Jamie M. Keck,Swapnil Parmar,Courtney Betts,Aurora Blucher,Christopher Boniface,Elmar Bucher,Erik A. Burlingame,Todd Camp,Koei Chin,Jennifer Eng,Joseph Estabrook,Heidi S. Feiler,Zhi Hu,Annette Kolodzie,Ben L. Kong,Marilyne Labrie,Jinho Lee,Patrick Leyshock,Souraya Mitri,Janice Patterson,Jessica L. Riesterer,Shamilene Sivagnanam,Julia Somers,Damir Sudar,Guillaume Thibault,Christina Zheng,Xiaolin Nan,Laura M. Heiser,Paul T. Spellman,George Thomas,Emek Demir,Young Hwan Chang,Lisa M. Coussens,Alexander R. Guimaraes,Christopher L. Corless,Jeremy Goecks,Raymond Bergan,Zahi Mitri,Gordon B. Mills,Joe W. Gray +42 more
TL;DR: The Omic and Multidimensional Spatial (OMS) Atlas as discussed by the authors was generated from four serial biopsies of a metastatic breast cancer patient during 3.5 years of therapy.
Journal ArticleDOI
CRS-207 immunotherapy expressing mesothelin, combined with chemotherapy as treatment for malignant pleural mesothelioma (MPM).
Raffit Hassan,Evan W. Alley,Hedy L. Kindler,Scott J. Antonia,Thierry Jahan,Somayeh Honarmand,Katherine McDougall,Chan C. Whiting,Nitya Nair,Amanda Enstrom,Ed Lemmens,Takahiro Tsujikawa,Sushil Kumar,Lisa M. Coussens,Aimee Murphy,Anish Thomas,Dirk G. Brockstedt +16 more
TL;DR: CRS-207 is a live, attenuated Listeria monocytogenes engineered to target mesothelin, a tumor-associated antigen over-expressed in several cancers, including MPM, an aggressive trea...