Lisa M. Coussens

TL;DR: The tumor microenvironment (TME) consists of cells, soluble factors, signaling molecules, extracellular matrix, and mechanical cues that can promote neoplastic transformation, support tumor growth and invasion, protect the tumor from host immunity, foster therapeutic resistance, and provide niches for dormant metastases to thrive.

TL;DR: To elucidate the features involved in the conversion of a normal cell-surface receptor gene into an oncogenic one, the complete nucleotide sequence of a human c-fms complementary DNA is determined.

TL;DR: A multiplexed immunohistochemical platform with computational image processing workflows, including image cytometry, enabling simultaneous evaluation of 12 biomarkers in one formalin-fixed paraffin-embedded tissue section is described, revealing differential immune profiles based on lymphoid and myeloid cell densities, correlating with human papilloma virus status and prognosis.

TL;DR: An initial evaluation of differences in the immune microenvironment of BC compared with nonadjacent normal tissue and the degree to which CTX may alter the complexity and presence of selective subsets of immune cells in tumors previously treated in the neoadjuvant setting are provided.

TL;DR: Recent advances support the hypothesis that enhanced states of local humoral and innate immune activation, in combination with suppressed cellular immunity and failed cytotoxic T cell anti-tumor immunity, alter cancer risk and therefore represent powerful targets for anti-cancer immunotherapeutics.