L
Lisa Törk
Researcher at Harvard University
Publications - 2
Citations - 162
Lisa Törk is an academic researcher from Harvard University. The author has contributed to research in topics: Epigenome & Regulation of gene expression. The author has an hindex of 2, co-authored 2 publications receiving 104 citations.
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Journal ArticleDOI
Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors
Sara E. S. Martin,Zhi-Wei Tan,Harri M. Itkonen,Damien Y. Duveau,Joao A. Paulo,John Janetzko,Paul L. Boutz,Lisa Törk,Frederick A. Moss,Craig J. Thomas,Steven P. Gygi,Michael B. Lazarus,Suzanne Walker +12 more
TL;DR: The structure-based evolution of OGT inhibitors culminating in compounds with low nanomolar inhibitory potency and on-target cellular activity are reported, providing insight into how to inhibit glycosyltransferases, a family of enzymes that has been notoriously refractory to inhibitor development.
Journal ArticleDOI
Light-controlled modulation of gene expression by chemical optoepigenetic probes
Surya A. Reis,Balaram Ghosh,J. Adam Hendricks,D. Miklos Szantai-Kis,Lisa Törk,Kenneth N. Ross,Justin Lamb,Willis Read-Button,Baixue Zheng,Hongtao Wang,Christopher Salthouse,Stephen J. Haggarty,Ralph Mazitschek,Ralph Mazitschek +13 more
TL;DR: This work presents a novel and generalizable approach, referred to as ‘Chemo-Optical Modulation of Epigenetically-regulated Transcription’ (COMET), enabling high-resolution, optical control of epigenetic mechanisms based on photochromic inhibitors of human histone deacetylases using visible light.