H
Harri M. Itkonen
Researcher at University of Oslo
Publications - 24
Citations - 1078
Harri M. Itkonen is an academic researcher from University of Oslo. The author has contributed to research in topics: Prostate cancer & Cancer. The author has an hindex of 13, co-authored 19 publications receiving 819 citations. Previous affiliations of Harri M. Itkonen include Oslo University Hospital & National Institutes of Health.
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Journal ArticleDOI
O-GlcNAc transferase integrates metabolic pathways to regulate the stability of c-MYC in human prostate cancer cells
Harri M. Itkonen,Sarah Minner,Ingrid Jenny Guldvik,Mareike Sandmann,Maria Christina Tsourlakis,Viktor Berge,Aud Svindland,Thorsten Schlomm,Ian G. Mills +8 more
TL;DR: It is reported that the HBP is activated in prostate cancer cells and that OGT is a central regulator of c-Myc stability in this setting and that c-MYC is a key target of OGT function in prostatecancer cells.
Journal ArticleDOI
Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors
Sara E. S. Martin,Zhi-Wei Tan,Harri M. Itkonen,Damien Y. Duveau,Joao A. Paulo,John Janetzko,Paul L. Boutz,Lisa Törk,Frederick A. Moss,Craig J. Thomas,Steven P. Gygi,Michael B. Lazarus,Suzanne Walker +12 more
TL;DR: The structure-based evolution of OGT inhibitors culminating in compounds with low nanomolar inhibitory potency and on-target cellular activity are reported, providing insight into how to inhibit glycosyltransferases, a family of enzymes that has been notoriously refractory to inhibitor development.
Journal ArticleDOI
Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer
Alfonso Urbanucci,Stefan J Barfeld,Ville Kytölä,Harri M. Itkonen,Ilsa Coleman,Daniel Vodak,Liisa Sjöblom,Xia Sheng,Teemu Tolonen,Sarah Minner,Christoph Burdelski,Kati Kivinummi,Annika Kohvakka,Steven Kregel,Steven Kregel,Mandeep Takhar,Mohammed Alshalalfa,Elai Davicioni,Nicholas Erho,Paul Lloyd,R. Jeffrey Karnes,Ashley E. Ross,Edward M. Schaeffer,Donald J. Vander Griend,Stefan Knapp,Stefan Knapp,Eva Corey,Felix Y. Feng,Peter S. Nelson,Peter S. Nelson,Fahri Saatcioglu,Karen E. Knudsen,Teuvo L.J. Tammela,Guido Sauter,Thorsten Schlomm,Matti Nykter,Tapio Visakorpi,Ian G. Mills,Ian G. Mills +38 more
TL;DR: It is shown that chromatin accessibility defines castration-resistant prostate cancer (CRPC) and that the deregulation of androgen receptor (AR) expression is a driver of chromatin relaxation and that AR/androgen-regulated bromodomain-containing proteins (BRDs) mediate this effect.
Journal ArticleDOI
UAP1 is overexpressed in prostate cancer and is protective against inhibitors of N-linked glycosylation.
Harri M. Itkonen,Nikolai Engedal,Eshrat Babaie,Morten Luhr,Ingrid Jenny Guldvik,Sarah Minner,J Hohloch,M.C. Tsourlakis,Thorsten Schlomm,Ian G. Mills +9 more
TL;DR: An enzyme, UAP1, is identified, which is highly overexpressed in prostate cancer and protects cancer cells from ER stress conferring a growth advantage.
Journal ArticleDOI
c-Myc Antagonises the Transcriptional Activity of the Androgen Receptor in Prostate Cancer Affecting Key Gene Networks
Stefan J Barfeld,Alfonso Urbanucci,Alfonso Urbanucci,Harri M. Itkonen,Ladan Fazli,Jessica L. Hicks,Bernd Thiede,Paul S. Rennie,Srinivasan Yegnasubramanian,Angelo M. DeMarzo,Ian G. Mills,Ian G. Mills,Ian G. Mills +12 more
TL;DR: Findings provide unbiased evidence that c-Myc overexpression deregulates the AR transcriptional program, which is thought to be a driving force in PCa.