L
Lisanne L. Blauw
Researcher at Leiden University Medical Center
Publications - 18
Citations - 325
Lisanne L. Blauw is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Cholesterylester transfer protein & Population. The author has an hindex of 8, co-authored 16 publications receiving 219 citations. Previous affiliations of Lisanne L. Blauw include Loyola University Medical Center.
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Journal ArticleDOI
Cholesteryl Ester Transfer Protein Influences High-Density Lipoprotein Levels and Survival in Sepsis
Mark Trinder,Kelly R. Genga,HyeJin Julia Kong,Lisanne L. Blauw,Cody Lo,Xuan Li,Mihai Cirstea,Yanan Wang,Patrick C.N. Rensen,James A. Russell,Keith R. Walley,John H. Boyd,Liam R. Brunham +12 more
TL;DR: A rare missense variant in CETP (cholesteryl ester transfer protein gene; rs1800777‐A) that was associated with significant reductions in HDL‐C levels during sepsis is identified, identifying CETP as a critical regulator of HDL levels and clinical outcomes duringSepsis.
Journal ArticleDOI
Diabetes incidence and glucose intolerance prevalence increase with higher outdoor temperature.
Lisanne L. Blauw,N. Ahmad Aziz,Martijn R. Tannemaat,C Alexander Blauw,Anton J. M. de Craen,Hanno Pijl,Patrick C.N. Rensen +6 more
TL;DR: The findings indicate that the diabetes incidence rate in the USA and prevalence of glucose intolerance worldwide increase with higher outdoor temperature, and these associations persisted after adjustment for obesity.
Journal ArticleDOI
Inhibition of Cholesteryl Ester Transfer Protein Preserves High-Density Lipoprotein Cholesterol and Improves Survival in Sepsis.
Mark Trinder,Yanan Wang,Christian M. Madsen,Christian M. Madsen,Tatjana Ponomarev,Lubos Bohunek,Brendan A. Daisely,HyeJin Julia Kong,Lisanne L. Blauw,Børge G. Nordestgaard,Anne Tybjærg-Hansen,Mark M. Wurfel,James A. Russell,James A. Russell,Keith R. Walley,Keith R. Walley,Patrick C.N. Rensen,John H. Boyd,Liam R. Brunham +18 more
TL;DR: Clinical genetics and humanized mouse models suggest that inhibiting CETP may preserve HDL levels and improve outcomes for individuals with sepsis.
Journal ArticleDOI
CETP (Cholesteryl Ester Transfer Protein) Concentration: A Genome-Wide Association Study Followed by Mendelian Randomization on Coronary Artery Disease.
Lisanne L. Blauw,Ruifang Li-Gao,Raymond Noordam,Renée de Mutsert,Stella Trompet,Jimmy F.P. Berbée,Yanan Wang,Jan B. van Klinken,Tim Christen,Diana van Heemst,Dennis O. Mook-Kanamori,Frits R. Rosendaal,J. Wouter Jukema,Patrick C.N. Rensen,Ko Willems van Dijk +14 more
TL;DR: This is the first genome-wide association study identifying independent variants that largely determine CETP concentration and it has been unequivocally demonstrated that low-density lipoprotein cholesterol lowering is proportionally associated with a lower CAD risk.
Journal ArticleDOI
Mendelian randomization reveals unexpected effects of CETP on the lipoprotein profile
Lisanne L. Blauw,Raymond Noordam,Sebastian Soidinsalo,C Alexander Blauw,Ruifang Li-Gao,Renée de Mutsert,Jimmy F.P. Berbée,Yanan Wang,Diana van Heemst,Frits R. Rosendaal,J. Wouter Jukema,Dennis O. Mook-Kanamori,Peter Würtz,Ko Willems van Dijk,Patrick C.N. Rensen +14 more
TL;DR: CETP is an important causal determinant of HDL and V LDL concentration and composition, which may imply that the CETP inhibitor anacetrapib decreased cardiovascular disease risk through specific reduction of small VLDL rather than LDL.