Inhibition of Cholesteryl Ester Transfer Protein Preserves High-Density Lipoprotein Cholesterol and Improves Survival in Sepsis.
Mark Trinder,Yanan Wang,Christian M. Madsen,Christian M. Madsen,Tatjana Ponomarev,Lubos Bohunek,Brendan A. Daisely,HyeJin Julia Kong,Lisanne L. Blauw,Børge G. Nordestgaard,Anne Tybjærg-Hansen,Mark M. Wurfel,James A. Russell,James A. Russell,Keith R. Walley,Keith R. Walley,Patrick C.N. Rensen,John H. Boyd,Liam R. Brunham +18 more
TLDR
Clinical genetics and humanized mouse models suggest that inhibiting CETP may preserve HDL levels and improve outcomes for individuals with sepsis.Abstract:
Background: The high-density lipoprotein hypothesis of atherosclerosis has been challenged by clinical trials of cholesteryl ester transfer protein (CETP) inhibitors, which failed to show significa...read more
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Supplement to: Time to treatment and mortality during mandated emergency care for sepsis.
TL;DR: More rapid completion of a 3‐hour bundle of sepsis care and rapid administration of antibiotics, but not rapid completed of an initial bolus of intravenous fluids, were associated with lower risk‐adjusted in‐hospital mortality.
Journal ArticleDOI
Cholesterol efflux pathways, inflammation, and atherosclerosis.
TL;DR: The causal relationship between plasma HDL-cholesterol levels and CVD has been called into question by Mendelian randomization studies and the majority of clinical trials not showing any benefit of plasma HDL cholesterol raising drugs on CVD as mentioned in this paper.
Journal ArticleDOI
The Endothelium Is Both a Target and a Barrier of HDL's Protective Functions.
TL;DR: In this article, a detailed understanding of the structure-function relationships underlying the multiple interactions of HDL with endothelial cells is expected to elucidate new targets and strategies for the treatment or prevention of various diseases.
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Baseline cardiometabolic profiles and SARS-CoV-2 infection in the UK Biobank.
TL;DR: In this article, the authors examined the impact of additional baseline cardiometabolic risk factors including high density lipoprotein-cholesterol (HDL-C), LDL-C, Apolipoprotein A-I (ApoA-I), triglycerides, hemoglobin A1c (HbA1c), and diabetes on SARS-CoV-2 infection risk.
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Good Cholesterol Gone Bad? HDL and COVID-19.
TL;DR: In this paper, the authors reviewed the complex role of HDL and SR-B1 in SARS-CoV-2-induced disease and showed that the ability of HDL to enhance or suppress virus infection appears to be dependent on the expression of the HDL receptor in the target cells.
References
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Journal ArticleDOI
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
Mervyn Singer,Clifford S. Deutschman,Christopher W. Seymour,Manu Shankar-Hari,Djillali Annane,Michael Bauer,Rinaldo Bellomo,Gordon R. Bernard,Jean-Daniel Chiche,Craig M. Coopersmith,Richard S. Hotchkiss,Mitchell M. Levy,John C. Marshall,Greg S. Martin,Steven M. Opal,Gordon D. Rubenfeld,Gordon D. Rubenfeld,Tom van der Poll,Jean Louis Vincent,Derek C. Angus +19 more
TL;DR: The task force concluded the term severe sepsis was redundant and updated definitions and clinical criteria should replace previous definitions, offer greater consistency for epidemiologic studies and clinical trials, and facilitate earlier recognition and more timely management of patients with sepsi or at risk of developing sepsic shock.
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2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
Mitchell M. Levy,Mitchell P. Fink,John C. Marshall,Edward Abraham,Derek C. Angus,Deborah J. Cook,Jonathan M. Cohen,Steven M. Opal,Jean Louis Vincent,Graham Ramsay +9 more
TL;DR: This document reflects a process whereby a group of experts and opinion leaders revisited the 1992 sepsis guidelines and found that apart from expanding the list of signs and symptoms of sepsi to reflect clinical bedside experience, no evidence exists to support a change to the definitions.
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The UK Biobank resource with deep phenotyping and genomic data
Clare Bycroft,Colin Freeman,Desislava Petkova,Desislava Petkova,Gavin Band,Lloyd T. Elliott,Kevin Sharp,Allan Motyer,Damjan Vukcevic,Olivier Delaneau,Olivier Delaneau,Jared O'Connell,Adrian Cortes,Adrian Cortes,Samantha Welsh,Alan Young,Mark Effingham,Gil McVean,Stephen Leslie,Naomi E. Allen,Peter Donnelly,Jonathan Marchini +21 more
TL;DR: Deep phenotype and genome-wide genetic data from 500,000 individuals from the UK Biobank is described, describing population structure and relatedness in the cohort, and imputation to increase the number of testable variants to 96 million.
Journal ArticleDOI
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
Mitchell M. Levy,Mitchell P. Fink,John C. Marshall,Edward Abraham,Derek C. Angus,Deborah J. Cook,Jonathan M. Cohen,Steven M. Opal,Jean Louis Vincent,Graham Ramsay +9 more
TL;DR: A hypothetical model for staging sepsis is presented, which, in the future, may better characterize the syndrome on the basis of predisposing factors and premorbid conditions, the nature of the underlying infection, the characteristics of the host response, and the extent of the resultant organ dysfunction.
Journal ArticleDOI
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016
Andrew Rhodes,Laura Evans,Waleed Alhazzani,Mitchell M. Levy,Massimo Antonelli,Ricard Ferrer,Anand Kumar,Jonathan E. Sevransky,Charles L. Sprung,Mark E. Nunnally,Bram Rochwerg,Gordon D. Rubenfeld,Derek C. Angus,Djillali Annane,Richard Beale,Geoffrey J. Bellinghan,Gordon R. Bernard,Jean Daniel Chiche,Craig M. Coopersmith,Daniel De Backer,Craig French,Seitaro Fujishima,Herwig Gerlach,Jorge Hidalgo,Steven M. Hollenberg,Alan E. Jones,Dilip R. Karnad,Ruth M. Kleinpell,Younsuck Koh,Thiago Lisboa,Flávia Ribeiro Machado,John J. Marini,John C. Marshall,John E. Mazuski,Lauralyn McIntyre,Anthony S. McLean,Sangeeta Mehta,Rui Moreno,John Myburgh,Paolo Navalesi,Osamu Nishida,Tiffany M. Osborn,Anders Perner,Colleen M. Plunkett,Marco Ranieri,Christa A. Schorr,Maureen A. Seckel,Christopher W. Seymour,Lisa Shieh,Khalid A. Shukri,Steven Q. Simpson,Mervyn Singer,B. Taylor Thompson,Sean R. Townsend,Thomas Van der Poll,Jean Louis Vincent,W. Joost Wiersinga,Janice L. Zimmerman,R. Phillip Dellinger +58 more
TL;DR: Although a significant number of aspects of care have relatively weak support, evidence-based recommendations regarding the acute management of sepsis and septic shock are the foundation of improved outcomes for these critically ill patients with high mortality.