L
Lise K. Sorensen
Researcher at University of Utah
Publications - 28
Citations - 5304
Lise K. Sorensen is an academic researcher from University of Utah. The author has contributed to research in topics: Angiogenesis & Signal transduction. The author has an hindex of 22, co-authored 26 publications receiving 4884 citations. Previous affiliations of Lise K. Sorensen include Howard Hughes Medical Institute.
Papers
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Journal ArticleDOI
Defective angiogenesis in mice lacking endoglin.
Dean Y. Li,Lise K. Sorensen,Benjamin S. Brooke,Lisa D. Urness,Elaine C. Davis,Douglas G. Taylor,Beth B. Boak,Daniel P. Wendel +7 more
TL;DR: It is shown that by gestational day 11.5, mice lacking endoglin die from defective vascular development, however, in contrast to mice lacking TGF-beta, vasculogenesis was unaffected and suggest a pathogenic mechanism for HHT1.
Journal ArticleDOI
Elastin is an essential determinant of arterial morphogenesis
Dean Y. Li,Benjamin S. Brooke,Elaine C. Davis,Robert P. Mecham,Lise K. Sorensen,Beth B. Boak,Ernst J. Eichwald,Mark T. Keating +7 more
TL;DR: Elastin has an unanticipated regulatory function during arterial development, controlling proliferation of smooth muscle and stabilizing arterial structure.
Journal ArticleDOI
A critical role for elastin signaling in vascular morphogenesis and disease
Satyajit K. Karnik,Benjamin S. Brooke,Antonio Bayes-Genis,Lise K. Sorensen,Joshua D. Wythe,Robert S. Schwartz,Mark T. Keating,Dean Y. Li +7 more
TL;DR: It is indicated that elastin stabilizes the arterial structure by inducing a quiescent contractile state in vascular smooth muscle cells, demonstrating that signaling pathways crucial for arterial morphogenesis can play an important role in the pathogenesis and treatment of vascular disease.
Journal ArticleDOI
Arteriovenous malformations in mice lacking activin receptor-like kinase-1
TL;DR: The early loss of anatomical, molecular and functional distinctions between arteries and veins indicates that Acvrl1 is required for developing distinct arterial and venous vascular beds.
Journal ArticleDOI
Netrins Promote Developmental and Therapeutic Angiogenesis
Brent D. Wilson,Masaaki,Kye Won Park,Arminda Suli,Lise K. Sorensen,Frederic Larrieu-Lahargue,Lisa D. Urness,Wonhee Suh,Jun Asai,Gerhardus A H Kock,Tina Thorne,Marcy Silver,Kirk R. Thomas,Chi Bin Chien,Douglas W. Losordo,Dean Y. Li +15 more
TL;DR: It is shown that netrins accelerate neovascularization in an in vivo model of ischemia and that they reverse neuropathy and vasculopathy in a diabetic murine model, suggesting a proangiogenic role forNetrins during vertebrate development.