L
Lisette Bok
Researcher at University Medical Center Groningen
Publications - 8
Citations - 515
Lisette Bok is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Inflammatory bowel disease & Inflammation. The author has an hindex of 7, co-authored 8 publications receiving 479 citations. Previous affiliations of Lisette Bok include University of Groningen.
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Journal ArticleDOI
Role of alkaline phosphatase in colitis in man and rats
A Tuin,Klaas Poelstra,A. de Jager-Krikken,Lisette Bok,W. Raaben,M. P. Velders,Gerard Dijkstra +6 more
TL;DR: The rat model demonstrates that oral administration of active iAP enzymes in the intestinal tract results in a significant reduction of inflammation, which provides new insight on IBD pathology and a novel treatment approach to this severe inflammatory disease.
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Decreased P‐glycoprotein (P‐gp/MDR1) expression in inflamed human intestinal epithelium is independent of PXR protein levels
Hans Blokzijl,Sara Vander Borght,Lisette Bok,Louis Libbrecht,M Geuken,Fiona A.J. van den Heuvel,Gerard Dijkstra,Tania Roskams,Han Moshage,Peter L.M. Jansen,Klaas Nico Faber +10 more
TL;DR: MDR1 expression is strongly decreased in inflamed IE of patients with gastrointestinal disorders and this is independent of PXR protein levels, suggesting low MDR1 levels may aggravate intestinal inflammation.
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Calprotectin - A novel noninvasive marker for intestinal allograft monitoring
TL;DR: Low stool calprotectin levels correlate well with a low risk for intestinal allograft rejection and may be reserved in the future for confirmation of rejection, eliminating protocol biopsies, and immunosuppressive changes could potentially be made before allografted injury.
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Opposite effect of oxidative stress on inducible nitric oxide synthase and haem oxygenase-1 expression in intestinal inflammation : anti-inflammatory effect of carbon monoxide
Gerard Dijkstra,Hans Blokzijl,Lisette Bok,M Homan,Harry van Goor,Klaas Nico Faber,Peter L.M. Jansen,Han Moshage +7 more
TL;DR: iNOS (NF‐κB driven) and HO‐1 (AP‐1 driven) represent mutually exclusive survival mechanisms in intestinal epithelial cells in response to cytokine exposure and oxidative stress.
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Up-regulation and cytoprotective role of epithelial multidrug resistance-associated protein 1 in inflammatory bowel disease
Hans Blokzijl,Axel Van Steenpaal,Sara Vander Borght,Lisette Bok,Louis Libbrecht,Marieke Tamminga,M Geuken,Tania Roskams,Gerard Dijkstra,Han Moshage,Peter L.M. Jansen,Klaas Nico Faber +11 more
TL;DR: Data show that MRP1 protects intestinal epithelial cells against inflammation-induced apoptotic cell death and provides a functional role for MRp1 in the inflamed intestinal epithelium of IBD patients.