L
Liu Lianxing
Publications - 9
Citations - 260
Liu Lianxing is an academic researcher. The author has contributed to research in topics: T-cell receptor & Immunotherapy. The author has an hindex of 4, co-authored 9 publications receiving 167 citations.
Papers
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Journal ArticleDOI
Targeting Alpha-Fetoprotein (AFP)-MHC Complex with CAR T-Cell Therapy for Liver Cancer.
Hong Liu,Yiyang Xu,Jingyi Xiang,Li Long,Shon Green,Zhiyuan Yang,Bryan Zimdahl,Jingwei Lu,Neal Cheng,Horan Lucas,Bin Liu,Sun Yan,Pei Wang,Juan E. Diaz,Lu Jin,Yoko Nakano,Javier Morales,Pengbo Zhang,Liu Lianxing,Binnaz K. Staley,Saul J. Priceman,Christine E. Brown,Stephen J. Forman,Vivien W. Chan,Cheng Liu +24 more
TL;DR: This study demonstrates that CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response and offers a promising new avenue for liver cancer immunotherapy.
Journal ArticleDOI
A novel antibody-TCR (AbTCR) platform combines Fab-based antigen recognition with gamma/delta-TCR signaling to facilitate T-cell cytotoxicity with low cytokine release.
Yiyang Xu,Zhiyuan Yang,Horan Lucas,Pengbo Zhang,Liu Lianxing,Bryan Zimdahl,Shon Green,Jingwei Lu,Javier Morales,David M. Barrett,Stephan A. Grupp,Vivien W. Chan,Hong Liu,Cheng Liu +13 more
TL;DR: It is demonstrated that AbTCR activates cytotoxic T-cell responses with a similar dose-response as CD28/CD3ζ CAR, yet does so with less cytokine release and results in T cells with a less exhausted phenotype, in comparative studies with the clinically validated CD137 (4-1BB)-based CAR, CTL019.
Journal ArticleDOI
Depleting T regulatory cells by targeting intracellular Foxp3 with a TCR mimic antibody
Tao Dao,Sung Soo Mun,Andrew Scott,Andrew Scott,Casey A. Jarvis,Tatyana Korontsvit,Zhiyuan Yang,Liu Lianxing,Martin G. Klatt,Manuel Guerreiro,Annamalai Selvakumar,Elliott J. Brea,Claire Y. Oh,Cheng Liu,David A. Scheinberg,David A. Scheinberg +15 more
TL;DR: A TCRm mAb targeting intracellular Foxp3 epitope represents an approach to deplete Tregs in xenografts of PBMCs from a healthy donor and ascites fluid from a cancer patient.
Patent
Chimeric antibody/t-cell receptor constructs and uses thereof
TL;DR: In this article, the authors provide chimeric antibody-TCR constructs comprising an antigen-binding module that specifically binds to a target antigen and a T cell receptor module capable of recruiting at least one TCR-associated signaling molecule.
Patent
Cells expressing chimeric activating receptors and chimeric stimulating receptors and uses thereof
TL;DR: In this article, a chimeric antibody-T cell receptor (TCR) and a chimeric signaling receptor (CSR) construct were used to generate T cells. But the authors did not provide methods of making and using these cells.