Annamalai Selvakumar

TL;DR: The studies support a model for KIR haplotype diversity based on six basic gene compositions, and suggest that the centromeric half of the KIR genomic region is comprised of three major combinations, while the telomeric half can assume a short form with either 2DS4 or KIR1D or a long form with multiple combinations of several stimulatory KIR genes.

TL;DR: This study uses a recently developed general strategy for monitoring CD4+ responses that overcomes the need for prior knowledge of epitope or HLA restriction to analyze a series of 31 cancer patients and healthy donors for the presence of CD4+, and shows that NY-ESO-1 peptide 80–109 was the most immunogenic, with 10 of 11 patients responding to this peptide.

TL;DR: The novel monitoring methodology used in this MAGE-3 study establishes that protein vaccination induces clear CD4+ T cell responses that correlate with Ab production, providing the framework for further evaluating integrated immune responses in vaccine settings and for optimizing these responses for clinical benefit.

TL;DR: It is demonstrated that fresh NK cells as well as IL-2-propagated NK cells from 2DS1-positive donors that are homozygous for the C1 ligand group are activated in vitro by B lymphoblastoid cell lines expressing the C2 group.

TL;DR: Findings indicate that alternative isoforms of ICAM-1 are significant physiologic adhesion structures which could play a distinct role in the functioning of the immune system of intact animals.