The invention relates to the technical field of synthesis of organic compounds and particularly relates to a preparation method of a beta-hydroxyphenyl selenide compound. The preparation method comprises the step of with aryl boronic acid with a structure presented by a formula (I), elemental selenium and an ethylene oxide derivative presented by a formula (II) as the raw materials, and carrying out insertion reaction on elemental selenium in a reaction solvent under the common effect of a copper catalyst, silver salt and alkali, so as to obtain the beta-hydroxyphenyl selenide compound represented by a formula (III), wherein R1 and R2 are respectively independently selected from one of H, a benzene ring, a naphthalene ring, a heterocyclic ring, a substituted benzene ring, linear alkyl, branched chain, halogen, nitryl and a cyano group.

Preparation method of beta-hydroxyphenyl selenide compound

The invention relates to a synthetic method of a diaryl substituted isoquinoline compound. The synthetic method comprises a step of enabling a diaryl carbonyl compound to react with aryl trifluoro-borate in a solvent in the presence of a palladium catalyst, a nitrogen-containing ligand and an accelerant so as to prepare the diaryl substituted isoquinoline compound through one step. The synthetic method is simple in reaction, convenient to operate and high in yield, is a brand-new synthetic method for the diaryl substituted isoquinoline compound, provides a new synthetic route for preparing the compound, and has a good scientific research value and an industrial potential.

Synthetic method of diaryl substituted isoquinoline compound

The invention relates to a method for synthesizing a diphenyl substituted quinazoline compound shown as the following formula (III). The method comprises the steps that in a solvent, in the presence of a catalyst, a N-donor ligand, an acid accelerator and alkali, a compound in the following formula (I) and a compound in the following formula (II) react, aftertreatment is carried out after the reaction is finished, and therefore the compound in the formula (III) is obtained. The formula is shown in the description, wherein R1 and R2 are independently selected from H and C1-C6 or C1-C6 alkoxy. According to the method, by means of comprehensive selection and cooperation of a nvoel proper substrate, the catalyst, the N-donor ligand, the acid accelerator, alkali, the solvent and the like, the range of the substrate is widened, the yield is good, and the diphenyl substituted quinazoline compound can be obtained. Therefore, the method has good application prospects and study value in the field of organic chemical synthesis, and the brand new method is provided for synthesis of the compound.

Method for synthesizing diphenyl substituted quinazoline compound

The invention provides a detection reagent for heavy metal ions and a synthesis method thereof, and belongs to the technical field of organic synthesis. The synthesis method of the reagent comprises the following steps: (1) dissolving o-phenylenediamine in a hydrochloric acid solution; (2) adding ethylenediaminetetraacetic acid and a hydrochloric acid solution into a three necked flask, heating and dissolving, and controlling reaction temperature; (3) slowly adding dropwise the solution obtained in the step (1) into the solution obtained in the step (2), and after the solution obtained in the step (1) is completely added dropwise into the solution obtained in the step (2), continuing reflux for reaction; and (4) naturally cooling the reaction solution at room temperature, filtering, cooling filtrate for 8 to 12h for precipitation of a colorless crystal, filtering by suction, washing a filtering cake with anhydrous ethanol and drying to obtain the target detection reagent. The reagent and lead, cadmium and copper ions can form stable complexes with strong absorption in an ultraviolet region, the stable complexes can be detected by an ultraviolet detector of a liquid chromatography, the synthesis process is simple, production is easy to realize, raw materials are easy to obtain, production cost is low, detection signals are stabile and have good reproducibility, and the detection reagent is worthy of wide application and promotion.

Detection reagent for heavy metal ions and synthesis method thereof

The invention discloses a preparation method for a diphenyl diselenium compound. According to the method, an arylboronic acid compound and elemental selenium serve as reaction raw materials, an organic solvent serves as a reaction solvent, under the effect of a silver catalyst, reaction is carried out so as to obtain the diphenyl diselenium compound, the reaction temperature is 100-140 DEG C, thereaction equation is shown in the specification, wherein R is a benzene ring, a naphthalene ring, a heterocyclic ring or a substituted benzene ring. The method has the beneficial effects that the tolerance of functional groups of substrates is high, and the range of the substrates is wide; and the raw materials and the catalyst are cheap and easily available, the conditions are mild, the post-treatment is simple, the yield and purity of a product are high, and the method is suitable for large-scale industrial production.

Preparation method for diphenyl diselenium compound

The invention provides a method for synthesizing an aryl or heteroaryl substituted quinazoline compound. According to the method, a copper compound and an iron compound serve as a bicomponent catalyst, and o-aminobenzyl alcohol and an aldehyde compound are enabled to react in the presence of an ammonium compound, alkali, organic ligands and TEMPO (Tetramethylpiperidine Oxide), thereby obtaining the aryl or heteroaryl substituted quinazoline compound. According to the method provided by the invention, the operation is simple, and the yield and purity of the product are high, so that the method has good industrial application potential.

Method for synthesizing aryl or heteroaryl substituted quinazoline compound

Synthetic method of quinazoline derivative

Diaryl diselenide compound synthesis method

The invention relates to a benzoselenadiazole-based conjugated polymer used for detecting heavy metal ions or heavy metal-like ions and a preparation method and application of the conjugated polymer The polymer has good fluorescent response on certain ions and can serve as a fluorescence sensor In addition, due to the fluorescent response, the polymer can be used for establishing a molecular logic gate with different guest molecules, so that the polymer has good scientific research values and application potential

Liu Miaochang

Papers

Method for synthesizing aryl or heteroaryl substituted quinazoline compound

Synthetic method of quinazoline derivative

Synthetic method of diaryl substituted isoquinoline compound

Diaryl diselenide compound synthesis method

Water-soluble conjugated polymer of benzoselenadiazole and preparation method and application of conjugated polymer