Patent
Method for synthesizing aryl or heteroaryl substituted quinazoline compound
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TLDR
In this paper, a method for synthesizing an aryl or heteroaryl substituted quinazoline compound was proposed, where a copper compound and an iron compound serve as a bicomponent catalyst, and o-aminobenzyl alcohol and an aldehyde compound are enabled to react in the presence of an ammonium compound, alkali, organic ligands and TEMPO (Tetramethylpiperidine Oxide).Abstract:
The invention provides a method for synthesizing an aryl or heteroaryl substituted quinazoline compound. According to the method, a copper compound and an iron compound serve as a bicomponent catalyst, and o-aminobenzyl alcohol and an aldehyde compound are enabled to react in the presence of an ammonium compound, alkali, organic ligands and TEMPO (Tetramethylpiperidine Oxide), thereby obtaining the aryl or heteroaryl substituted quinazoline compound. According to the method provided by the invention, the operation is simple, and the yield and purity of the product are high, so that the method has good industrial application potential.read more
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References
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Journal ArticleDOI
Gallium(III) triflate-catalyzed one-pot selective synthesis of 2,3-dihydroquinazolin-4(1H)-ones and quinazolin-4(3H)-ones
TL;DR: In this article, a series of 2,3-dihydroquinazolin-4(1H)-and quinazolin 4(3H)-ones were synthesized by one-pot reaction using isatoic anhydride, ammonium acetate (or amines), and aldehydes in ethanol or in DMSO under mild conditions.
Journal ArticleDOI
CuCl/DABCO/4-HO-TEMPO-Catalyzed Aerobic Oxidative Synthesis of 2-Substituted Quinazolines and 4H-3,1-Benzoxazines
TL;DR: The Cu/N-ligand/TEMPO catalytic system was first applied to the aerobic oxidative synthesis of heterocycles and 2-substituted quinazolines and 4H-3,1-benzoxazines were synthesized efficiently from the one-pot reaction of aldehydes with 2-aminobenzylamines and 2 -aminobenzyl alcohols.
Journal ArticleDOI
A Cooperative Catalytic System of Platinum/Iridium Alloyed Nanoclusters and a Dimeric Catechol Derivative: An Efficient Synthesis of Quinazolines Through a Sequential Aerobic Oxidative Process
TL;DR: A cooperative catalytic system of heterogeneous polymer-supported bi-metallic platinum/iridium (Pt/Ir) alloyed nanoclusters and 5,5′,6,6′-tetrahydroxy-1,1′-spiro-bisindane (TTSBI) enabled the facile preparation of quinazoline derivatives with low catalyst loadings and broad substrate scope under mild aerobic oxidative conditions as discussed by the authors.
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A convenient one-pot procedure for the synthesis of 2-aryl quinazolines using active MnO2 as oxidant
Journal ArticleDOI
Synthesis of 2-substituted quinazolines via iridium catalysis
TL;DR: An iridium-catalyzed hydrogen transfer reaction was successfully applied in the synthesis of 2-substituted quinazolines in moderate yields starting from aldehydes or alcohols with 2-aminobenzylamines.