Patent
Synthetic method of quinazoline derivative
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The article was published on 2015-04-08. It has received 5 citations till now.read more
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Patent
Synthetic method of diaryl substituted isoquinoline compound
TL;DR: In this article, a diaryl substituted isoquinoline compound was synthesized in a solvent in the presence of a palladium catalyst, a nitrogen-containing ligand and an accelerant.
Patent
Synthesis method for medical intermediate quinazoline derivative
TL;DR: In this article, a synthesis method for medical intermediate quinazoline derivative shown in the formula (I) is presented, which includes the steps that under the atmosphere of organic solvent and oxygen, a mixture of a copper compound, organic ligand and 2,2,6,6-tetramethyl piperidine-1oxide is used as a compound catalytic system, in the presence of oxidizing agents and alkali, a compound in formula (II), a compound and an amine source compound first react for 10-14 hours in a stirred mode at
Patent
Synthetic method of imidazole [1,2-a:3,4-a'] bipyridine salt compound
TL;DR: In this article, a synthetic method of an imidazole [1,2-a:3,4-a]- bipyridine salt compound is described, which consists of adding a pyridyl pyridine compound, bromo acetophenone compound, a cobalt/copper co-catalysis system, a cesium salt and a solvent into a reaction tube in sequence; putting the reaction tube at the temperature of 120 to 140 DEG C in an air atmosphere for a stirring reaction, wherein the stirring reaction time lasts for greater than or
Patent
Method for synthesizing nitrogen heterocyclic ring drug intermediates
TL;DR: In this article, the authors presented a method for synthesizing nitrogen heterocyclic ring drug intermediates using a mixture of a copper compound, organic ligands and 2,2,6,6-tetramethyl piperidine-1oxide.
Patent
Synthesis method for 2-substituted quinazoline heterocyclic compound
TL;DR: In this article, a synthesis method for a 2-substituted quinazoline heterocyclic compound was presented, where 2-aminobenzylalcohol and nitrile are subjected to an oxidation-cyclization reaction in air under the alkaline condition to prepare the two-substantituted QH compounds, and no transition metal catalyst or ligand is needed.
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Journal ArticleDOI
CuCl/DABCO/4-HO-TEMPO-Catalyzed Aerobic Oxidative Synthesis of 2-Substituted Quinazolines and 4H-3,1-Benzoxazines
TL;DR: The Cu/N-ligand/TEMPO catalytic system was first applied to the aerobic oxidative synthesis of heterocycles and 2-substituted quinazolines and 4H-3,1-benzoxazines were synthesized efficiently from the one-pot reaction of aldehydes with 2-aminobenzylamines and 2 -aminobenzyl alcohols.
Journal ArticleDOI
Cu(II)-catalyzed selective aerobic oxidation of alcohols under mild conditions.
Nan Jiang,Arthur J. Ragauskas +1 more
TL;DR: An efficient four-component system consisting of acetamido-TEMPO/Cu(ClO4)2/TMDP/DABCO in DMSO has been developed for room-temperature aerobic alcohol oxidation and could be converted into their corresponding aldehydes or ketones in good to excellent yields.
Patent
Synthesis of quinazoline ketone compounds
TL;DR: In this paper, a method for synthesizing quinazolinone compounds using trifluoro mesylate as a catalyst is described. But the method is not suitable for high reaction yield up to more than 85 percent generally, advanced and reasonable process routes, mild reaction conditions, little dosage of the catalyst, reutilization and substantially no three wastes.