Showing papers by "Liu-Zhu Gong published in 2018"
TL;DR: The transient chiral C1-ammonium enolate generated from pentafluorophenyl ester and nucleophilic Lewis base is nicely compatible with the copper intermediate formed from N, N-di- t-butyldiaziridinone and Cu(I) to allow for high levels of stereochemical control.
Abstract: An enantioselective α-amination of esters by a Lewis base/copper(I) cooperative catalysis strategy has been developed The transient chiral C1-ammonium enolate generated from pentafluorophenyl ester and nucleophilic Lewis base is nicely compatible with the copper intermediate formed from N,N-di-t-butyldiaziridinone and Cu(I) to allow for high levels of stereochemical control The cooperative catalytic reaction leads to a diverse set of highly enantioenriched hydantoins in good yields with excellent enantioselectivities (90–99% ee)
69 citations
TL;DR: In this paper, a one-step transformation of styrenes, allylic alcohols, and syngas to α-quaternary chiral aldehydes in a multi-catalyst system consisting of a rhodium(I) complex, a palladium(0), a chiral Bronsted acid catalyst, and an achiral amine was realized with high yields and asymmetric allylation reaction with high enantioselectivities.
60 citations
TL;DR: A PdII -catalyzed asymmetric aminohydroxylation of 1,3-dienes with N-tosyl-2-aminophenols was developed by making use of a chiral pyridinebis(oxazoline) ligand to provide direct and efficient access to chiral 3,4-dihydro-2H-1, 4-benzoxazines in high yield and enantioselectivity.
Abstract: A PdII -catalyzed asymmetric aminohydroxylation of 1,3-dienes with N-tosyl-2-aminophenols was developed by making use of a chiral pyridinebis(oxazoline) ligand. The highly regioselective reaction provides direct and efficient access to chiral 3,4-dihydro-2H-1,4-benzoxazines in high yield and enantioselectivity (up to 96:4 e.r.). The reaction employs readily available N-tosyl-2-aminophenols as a unique aminohydroxylation reagent and is complementary to known asymmetric aminohydroxylation methods.
59 citations
TL;DR: A palladium(II)-catalyzed asymmetric 1,2-diamination of 1,3-dienes with readily available dialkylureas was established by using a chiral pyridine-oxazoline ligand to give 4-vinylimidazolidin-2-ones in high yields and with excellent levels of enantioselectivity.
46 citations
TL;DR: A palladium-catalyzed, enantioselective allylic C-H alkylation of 1,4-pentadienes with 5 H-thiazol-4-ones has been developed and led to linear and branched allylation products, respectively.
39 citations
TL;DR: A palladium-catalyzed asymmetric α-allylation of aldehydes with alkynes has been established by integrating the catalysis of enamine and chiral hydridopalladium complex that is reversibly formed from the oxidative addition of Pd(0) to chiral phosphoric acid.
35 citations
TL;DR: A palladium-catalyzed enantioselective carboannulation of 1,3-dienes and aryl iodides has been established by using a BINOL-based phosphoramidite ligand, providing indane derivatives with high levels of enantiOSElectivity.
21 citations
19 citations
TL;DR: An efficient synthesis of highly enantio-enriched tetrahydropyrans from readily available aldehydes, allylboronates, and syngas has been established by multiply relay catalysis of rhodium and chiral phosphoric acid.
Abstract: An efficient synthesis of highly enantio-enriched tetrahydropyrans from readily available aldehydes, allylboronates, and syngas has been established by multiply relay catalysis of rhodium and chiral phosphoric acid. The cascade reaction integrates the asymmetric allylboration of aldehydes and alkene hydroformylation, providing a structurally diverse range of products with different workup procedures. The concise synthesis of key chiral building blocks to access herboxidiene and leucascandrolide A demonstrates the high synthetic utility of this method. The cascade reaction employing alkenes to replace aldehydes was also successful.
10 citations
1 citations