L
Loredan S. Niculescu
Researcher at Romanian Academy
Publications - 32
Citations - 569
Loredan S. Niculescu is an academic researcher from Romanian Academy. The author has contributed to research in topics: Cholesterol & Medicine. The author has an hindex of 13, co-authored 27 publications receiving 421 citations.
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Journal ArticleDOI
MiR-486 and miR-92a Identified in Circulating HDL Discriminate between Stable and Vulnerable Coronary Artery Disease Patients
Loredan S. Niculescu,Natalia Simionescu,Gabriela M. Sanda,Mihaela G. Carnuta,Camelia S. Stancu,Andreea C. Popescu,Mihaela Roxana Popescu,Adelina Vlad,D. Dimulescu,Maya Simionescu,Anca V. Sima +10 more
TL;DR: Two circulating miRNAs that in association with some lipid metabolism biomarkers can be used as an additional tool to designate vulnerable CAD patients are identified.
Journal ArticleDOI
Dysfunctional high-density lipoproteins have distinct composition, diminished anti-inflammatory potential and discriminate acute coronary syndrome from stable coronary artery disease patients
Mihaela G. Carnuta,Camelia S. Stancu,Laura Toma,Gabriela M. Sanda,Loredan S. Niculescu,Mariana Deleanu,Mariana Deleanu,Andreea C. Popescu,Mihaela Roxana Popescu,Adelina Vlad,D. Dimulescu,Maya Simionescu,Anca V. Sima +12 more
TL;DR: The assessed panel of markers correlates with the reduced anti-inflammatory potential of HDL subfractions isolated from ACS and SA patients (mostly for HDL3 from ACS) and can discriminate between these two groups of CAD patients.
Journal ArticleDOI
Phenolic Compounds Exerting Lipid-Regulatory, Anti-Inflammatory and Epigenetic Effects as Complementary Treatments in Cardiovascular Diseases.
Laura Toma,Gabriela M. Sanda,Loredan S. Niculescu,Mariana Deleanu,Mariana Deleanu,Anca V. Sima,Camelia S. Stancu +6 more
TL;DR: The present review is focused on the latest data about phenolic compounds and aims to collect and correlate the reliable existing knowledge concerning their molecular mechanisms of action to counteract important risk factors that contribute to the initiation and development of atherosclerosis: dyslipidemia, and oxidative and inflammatory-stress.
Journal ArticleDOI
Analysis of circulating microRNAs that are specifically increased in hyperlipidemic and/or hyperglycemic sera.
TL;DR: Data show a statistically significant correlation of the analyzed miRNA with increased lipids, specifically with α- and β-lipoproteins, and CRP and IL-1β levels in HL and/or HG sera, suggesting a contribution of these miRNAs to the atherosclerotic process.
Journal ArticleDOI
Hyperglycemia Determines Increased Specific MicroRNAs Levels in Sera and HDL of Acute Coronary Syndrome Patients and Stimulates MicroRNAs Production in Human Macrophages.
Natalia Simionescu,Loredan S. Niculescu,Mihaela G. Carnuta,Gabriela M. Sanda,Camelia S. Stancu,Andreea C. Popescu,Mihaela Roxana Popescu,Adelina Vlad,D. Dimulescu,Maya Simionescu,Anca V. Sima +10 more
TL;DR: Exposure of human macrophages to ACS compared to SA sera determines the upregulation of Drosha, DGCR8 and Dicer expression and the increase of selected miRNAs production, the effect being augmented by an increased glucose concentration.