M
Mariana Deleanu
Researcher at Romanian Academy
Publications - 25
Citations - 521
Mariana Deleanu is an academic researcher from Romanian Academy. The author has contributed to research in topics: Endoplasmic reticulum & Oxidative stress. The author has an hindex of 11, co-authored 22 publications receiving 318 citations. Previous affiliations of Mariana Deleanu include University of Agronomic Sciences and Veterinary Medicine of Bucharest.
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Journal ArticleDOI
Lipopolysaccharide-induced inflammation in monocytes/macrophages is blocked by liposomal delivery of G i -protein inhibitor
Monica Madalina Tucureanu,Daniela Rebleanu,Cristina Ana Constantinescu,Mariana Deleanu,Geanina Voicu,Elena Butoi,Manuela Calin,Ileana Manduteanu +7 more
TL;DR: The potential of liposomal GOT in blocking LPS proinflammatory effects in monocytes/macrophages is demonstrated and reduced monocyte adhesion and chemotaxis.
Journal ArticleDOI
Probiotics determine hypolipidemic and antioxidant effects in hyperlipidemic hamsters.
TL;DR: The data support the administration of probiotics to humans because of their hypolipidemic effects (through decreasing intestinal NPC1L1 and MTTP) and antioxidant effects (stimulating HDL-associated paraoxonase-1).
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VCAM-1 directed target-sensitive liposomes carrying CCR2 antagonists bind to activated endothelium and reduce adhesion and transmigration of monocytes.
Manuela Calin,Daniela Stan,Martin Schlesinger,Viorel Simion,Mariana Deleanu,Cristina Ana Constantinescu,Ana-Maria Gan,Monica Pirvulescu,Elena Butoi,Ileana Manduteanu,Marian Bota,Marius Enachescu,Lubor Borsig,Gerd Bendas,Maya Simionescu +14 more
TL;DR: It is reported that Vp-TSL-Tj binds specifically to activated EC in vitro and in situ, release the entrapped Teijin and prevent the transmigration of monocytes through activated EC, the first evidence that nanocarriers which transport and release chemokine inhibitors at specific pathological sites can reduceChemokine-dependent inflammatory processes.
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Dysfunctional high-density lipoproteins have distinct composition, diminished anti-inflammatory potential and discriminate acute coronary syndrome from stable coronary artery disease patients
Mihaela G. Carnuta,Camelia S. Stancu,Laura Toma,Gabriela M. Sanda,Loredan S. Niculescu,Mariana Deleanu,Mariana Deleanu,Andreea C. Popescu,Mihaela Roxana Popescu,Adelina Vlad,D. Dimulescu,Maya Simionescu,Anca V. Sima +12 more
TL;DR: The assessed panel of markers correlates with the reduced anti-inflammatory potential of HDL subfractions isolated from ACS and SA patients (mostly for HDL3 from ACS) and can discriminate between these two groups of CAD patients.
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Phenolic Compounds Exerting Lipid-Regulatory, Anti-Inflammatory and Epigenetic Effects as Complementary Treatments in Cardiovascular Diseases.
Laura Toma,Gabriela M. Sanda,Loredan S. Niculescu,Mariana Deleanu,Mariana Deleanu,Anca V. Sima,Camelia S. Stancu +6 more
TL;DR: The present review is focused on the latest data about phenolic compounds and aims to collect and correlate the reliable existing knowledge concerning their molecular mechanisms of action to counteract important risk factors that contribute to the initiation and development of atherosclerosis: dyslipidemia, and oxidative and inflammatory-stress.