L
Loren Dean Williams
Researcher at Georgia Institute of Technology
Publications - 173
Citations - 8442
Loren Dean Williams is an academic researcher from Georgia Institute of Technology. The author has contributed to research in topics: Ribosomal RNA & RNA. The author has an hindex of 49, co-authored 160 publications receiving 7509 citations. Previous affiliations of Loren Dean Williams include University of Mississippi Medical Center & University of Nebraska Medical Center.
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Journal ArticleDOI
Structural comparison of anticancer drug-DNA complexes: adriamycin and daunomycin.
Christin A. Frederick,Loren Dean Williams,Giovanni Ughetto,G. A. Van Der Marel,J. H. Van Boom,Alexander Rich,Andrew H.-J. Wang +6 more
TL;DR: The observed changes in the overall structures of the ternary complexes amplify the small chemical differences between these two antibiotics and provide a possible explanation for the significantly different clinical activities of these important drugs.
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The B-DNA Dodecamer at High Resolution Reveals a Spine of Water on Sodium†,‡
TL;DR: In this article, a very accurate addition (called structure X here) to the B-DNA dodecamer family of X-ray structures was described, which confirmed the observation of Drew and Dickerson [(1981) J. Mol. Biol. 151, 535−556] that the spine of hydration in AT tract DNA is two layers deep.
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RNA backbone: consensus all-angle conformers and modular string nomenclature (an RNA Ontology Consortium contribution).
Jane S. Richardson,Bohdan Schneider,Laura Weston Murray,Gary J. Kapral,R.M. Immormino,Jeffrey J. Headd,David S. Richardson,Daniela Ham,Eli Hershkovits,Loren Dean Williams,Kevin S. Keating,Anna Marie Pyle,David Micallef,John D. Westbrook,Helen M. Berman +14 more
TL;DR: A consensus classification and nomenclature are defined for RNA backbone structure using all of the backbone torsion angles and this new backbone system will combine with others that define base pairs, base-stacking, and hydrogen-bond relationships to provide a full description of RNA structural motifs.
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Structure of DNA-porphyrin complex.
Leigh Ann Lipscomb,Fang Xiao Zhou,Steven R. Presnell,Rebecca J. Woo,Mary Elizabeth Peek,R. Richard Plaskon,Loren Dean Williams +6 more
TL;DR: In this article, the porphyrin system was shown to be extensively stabilized by electrostatic interactions between positively charged nitrogen atoms of the pyridyl rings and negatively charged phosphate oxygen atoms of DNA.
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X-ray structure of a DNA decamer containing 7,8-dihydro-8-oxoguanine
Leigh Ann Lipscomb,Mary Elizabeth Peek,Marshall L. Morningstar,Susan M. Verghis,Elizabeth M. Miller,Alexander Rich,John M. Essigmann,Loren Dean Williams +7 more
TL;DR: Additional structural analysis indicates that conversion of G to G(O) would not significantly influence the glycosidic torsion preference of the nucleoside, and the structure allows us to identify probable elements by which the DNA repair protein MutM recognizes its substrates.