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Alexander Rich
Researcher at Massachusetts Institute of Technology
Publications - 541
Citations - 51984
Alexander Rich is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: DNA & RNA. The author has an hindex of 115, co-authored 539 publications receiving 50171 citations. Previous affiliations of Alexander Rich include Vanderbilt University & Northwestern University.
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Journal ArticleDOI
Molecular structure of a left-handed double helical DNA fragment at atomic resolution
Andrew H.-J. Wang,Gary J. Quigley,F. Kolpak,J.L. Crawford,J. H. Van Boom,G. A. Van Der Marel,Alexander Rich +6 more
TL;DR: The DNA fragment d(CpGpCpC pGp CpG pG) crystallises as a left-handed double helical molecule with Watson–Crick base pairs and an antiparallel organisation of the sugar phosphate chains.
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Spontaneous assembly of a self-complementary oligopeptide to form a stable macroscopic membrane.
TL;DR: This work has shown that a 16-residue peptide has a characteristic beta-sheet circular dichroism spectrum in water and spontaneously assembles to form a macroscopic membrane, which may be a model for studying the insoluble peptides found in certain neurological disorders.
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Extensive neurite outgrowth and active synapse formation on self-assembling peptide scaffolds
TL;DR: A new type of self-assembling peptide (sapeptide) scaffolds that serve as substrates for neurite outgrowth and synapse formation is described, and they did not elicit a measurable immune response or tissue inflammation when introduced into animals.
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Sequence-specific recognition of double helical nucleic acids by proteins.
TL;DR: It is concluded that a single hydrogen bond is inadequate for uniquely identifying any particular base pair, as this leads to numerous degeneracies, but using two hydrogen bonds, fidelity of base pair recognition may be achieved.
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Nucleotide sequence of human monocyte interleukin 1 precursor cDNA.
Philip E. Auron,Andrew C. Webb,Lanny J. Rosenwasser,Steven F. Mucci,Alexander Rich,Sheldon M. Wolff,Charles A. Dinarello +6 more
TL;DR: The cDNA nucleotide sequence suggests that IL-1 is initially translated as a precursor molecule that is subsequently processed into the 15,000-20,000 Mr protein usually associated with IL- 1 activity.