J
J. H. Van Boom
Researcher at Leiden University
Publications - 492
Citations - 21070
J. H. Van Boom is an academic researcher from Leiden University. The author has contributed to research in topics: Base pair & DNA. The author has an hindex of 69, co-authored 492 publications receiving 20576 citations. Previous affiliations of J. H. Van Boom include University of Illinois at Urbana–Champaign & Netherlands Cancer Institute.
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Journal ArticleDOI
Molecular structure of a left-handed double helical DNA fragment at atomic resolution
Andrew H.-J. Wang,Gary J. Quigley,F. Kolpak,J.L. Crawford,J. H. Van Boom,G. A. Van Der Marel,Alexander Rich +6 more
TL;DR: The DNA fragment d(CpGpCpC pGp CpG pG) crystallises as a left-handed double helical molecule with Watson–Crick base pairs and an antiparallel organisation of the sugar phosphate chains.
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Regulation of cellulose synthesis in Acetobacter xylinum by cyclic diguanylic acid.
Peter Ross,Haim Weinhouse,Yehoshua Aloni,Dorit Michaeli,Patricia Weinberger-Ohana,Raphael Mayer,Sergei Braun,E. De Vroom,G. A. Van Der Marel,J. H. Van Boom,Moshe Benziman +10 more
TL;DR: The cellulose synthase activator (CSA) has now been identified as bis-(3′ → 5′)-cyclic diguanylic acid (5′G3′p 5′G 3′p) on the basis of mass spectroscopic data, nuclear magnetic resonance analysis and comparison with chemically synthesized material.
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Major transcript of the frameshifted coxII gene from trypanosome mitochondria contains four nucleotides that are not encoded in the DNA.
TL;DR: It is concluded that four extra, reading frame-restoring nucleotides are added during or after transcription of the frameshift gene by an RNA-editing process.
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Iodonium ion promoted reactions at the anomeric centre. II An efficient thioglycoside mediated approach toward the formation of 1,2-trans linked glycosides and glycosidic esters
TL;DR: NIS together with a catalytic amount of trifluoromethanesulfonic acid proved to be very convenient for the rapid, high-yielding and stereoselective (1,2-trans) glycosidation of esterified thioglycosides with glycosyl acceptors.
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Structural comparison of anticancer drug-DNA complexes: adriamycin and daunomycin.
Christin A. Frederick,Loren Dean Williams,Giovanni Ughetto,G. A. Van Der Marel,J. H. Van Boom,Alexander Rich,Andrew H.-J. Wang +6 more
TL;DR: The observed changes in the overall structures of the ternary complexes amplify the small chemical differences between these two antibiotics and provide a possible explanation for the significantly different clinical activities of these important drugs.