L
Lorena R. Pecanha
Researcher at Federal University of Rio de Janeiro
Publications - 1
Citations - 144
Lorena R. Pecanha is an academic researcher from Federal University of Rio de Janeiro. The author has contributed to research in topics: Innate immune system & Interleukin 10. The author has an hindex of 1, co-authored 1 publications receiving 133 citations.
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Tuberculosis Is Associated with a Down-Modulatory Lung Immune Response That Impairs Th1-Type Immunity
Alexandre S. de Almeida,Patrícia Martins Lago,Neio Boechat,Richard C. Huard,Richard C. Huard,Luiz Claudio Oliveira Lazzarini,Luiz Claudio Oliveira Lazzarini,Adalberto R. Santos,Marcelo Nociari,Hongxia Zhu,Beatriz M. Perez-Sweeney,Heejung Bang,Quanhong Ni,Jie Huang,Andrea L. Gibson,Vera C. Flores,Vera C. Flores,Lorena R. Pecanha,Afrânio Lineu Kritski,José Roberto Lapa e Silva,José Roberto Lapa e Silva,John L. Ho,John L. Ho +22 more
TL;DR: Low levels of NO synthase-2 produced by alveolar macrophages at TB diagnosis, along with the heightened amounts of suppressive mediators, support the conclusion that M. tuberculosis actively promotes down-modulatory mediators to counteract Th1-type and innate immunity as an immunopathological strategy.