L
Luiz Claudio Oliveira Lazzarini
Researcher at Federal University of Rio de Janeiro
Publications - 17
Citations - 1321
Luiz Claudio Oliveira Lazzarini is an academic researcher from Federal University of Rio de Janeiro. The author has contributed to research in topics: Mycobacterium tuberculosis & Tuberculosis. The author has an hindex of 14, co-authored 17 publications receiving 1251 citations. Previous affiliations of Luiz Claudio Oliveira Lazzarini include Cornell University.
Papers
More filters
Journal ArticleDOI
PCR-based method to differentiate the subspecies of the Mycobacterium tuberculosis complex on the basis of genomic deletions
Richard C. Huard,Luiz Claudio Oliveira Lazzarini,W. Ray Butler,Dick van Soolingen,John L. Ho +4 more
TL;DR: This MtbC PCR typing panel provides an advanced approach to determine the subspecies of MtbB isolates and to differentiate them from clinically important MOTT species and may be applied for practical clinical and epidemiological use.
Journal ArticleDOI
Novel Genetic Polymorphisms That Further Delineate the Phylogeny of the Mycobacterium tuberculosis Complex
Richard C. Huard,Michel Fabre,Petra E. W. de Haas,Luiz Claudio Oliveira Lazzarini,Dick van Soolingen,Debby Cousins,John L. Ho +6 more
TL;DR: Evaluating known MTC phylogenetic markers in a larger collection of tubercle bacilli and evaluating additional recently reported MTC species-specific and interspecific polymorphisms add to the genetic definitions of several MTC organisms as well as fine-tune current models for the evolutionary history of the MTC.
Journal ArticleDOI
Down-Modulation of Lung Immune Responses by Interleukin-10 and Transforming Growth Factor β (TGF-β) and Analysis of TGF-β Receptors I and II in Active Tuberculosis
M. Glória Bonecini-Almeida,John L. Ho,Neio Boechat,Richard C. Huard,Sadhana Chitale,Howard Doo,Jiayuan Geng,Lorena Rego,Luiz Claudio Oliveira Lazzarini,Luiz Claudio Oliveira Lazzarini,Afrânio Lineu Kritski,Warren D. Johnson,Timothy A. McCaffrey,José Roberto Lapa e Silva +13 more
TL;DR: The data suggest that the combined production of the immunosuppressants IL-10 and TGF-β, as well as coexpression of T GF-β RI and RII, may act to down-modulate host anti-Mycobacterium tuberculosis immunity and thereby allow uncontrolled bacterial replication and overt disease.
Journal ArticleDOI
Tuberculosis Is Associated with a Down-Modulatory Lung Immune Response That Impairs Th1-Type Immunity
Alexandre S. de Almeida,Patrícia Martins Lago,Neio Boechat,Richard C. Huard,Richard C. Huard,Luiz Claudio Oliveira Lazzarini,Luiz Claudio Oliveira Lazzarini,Adalberto R. Santos,Marcelo Nociari,Hongxia Zhu,Beatriz M. Perez-Sweeney,Heejung Bang,Quanhong Ni,Jie Huang,Andrea L. Gibson,Vera C. Flores,Vera C. Flores,Lorena R. Pecanha,Afrânio Lineu Kritski,José Roberto Lapa e Silva,José Roberto Lapa e Silva,John L. Ho,John L. Ho +22 more
TL;DR: Low levels of NO synthase-2 produced by alveolar macrophages at TB diagnosis, along with the heightened amounts of suppressive mediators, support the conclusion that M. tuberculosis actively promotes down-modulatory mediators to counteract Th1-type and innate immunity as an immunopathological strategy.
Journal ArticleDOI
Discovery of a Novel Mycobacterium tuberculosis Lineage That Is a Major Cause of Tuberculosis in Rio de Janeiro, Brazil
Luiz Claudio Oliveira Lazzarini,Luiz Claudio Oliveira Lazzarini,Richard C. Huard,Neio Boechat,Harrison Magdinier Gomes,Maranibia Aparecida Cardoso Oelemann,Natalia Kurepina,Elena Shashkina,Fernanda Carvalho de Queiroz Mello,Andrea L. Gibson,Milena J. Virginio,Ana Grazia Marsico,W. Ray Butler,Barry N. Kreiswirth,Philip Noel Suffys,José Roberto Lapa e Silva,José Roberto Lapa e Silva,John L. Ho +17 more
TL;DR: The identification of RDRio strains outside of Brazil points to the ongoing intercontinental dissemination of this important genotype, and the high prevalence of this genotype may be related to enhanced virulence, transmissibility, and/or specific adaptation to a Euro-Latin American host population.