Loreto Martínez-González

TL;DR: The discovery of 2,4-thiazolidinedione derivatives endowed with a suitable cellular safety profile are reported on, believed to be the first balanced, nontoxic, dual-acting compounds hitting tau cascade at two different hubs.

TL;DR: Data show for the first time the in vivo modulation of TDP-43 toxicity by CK-1δ inhibition with IGS-2.7, which may explain the benefits in the preservation of spinal motor neurons and point to the relevance of CK- 1δ inhibitors in a future disease-modifying treatment for ALS.

TL;DR: New nitrocatechol COMT inhibitors based on naturally occurring caffeic acid and caffeic Acid phenethyl ester displayed potent inhibition of peripheral and cerebral COMT within the nanomolar range and confirmed that the major interactions with COMT were established via the nitrocamine ring.

TL;DR: A small molecule, the phenothiazine FD44, is identified that binds the interaction surface between NCS-1 and Ric8a, preventing the formation of the complex, and it restores normal synapse number and associative learning in a Drosophila FXS model.

TL;DR: In this article, a dual GSK-3β inhibitor/Nrf2 inducer was designed to increase the neuronal resistance to oxidative stress and neuroinflammation in a C. elegans model.