L
Lothar Hennighausen
Researcher at National Institutes of Health
Publications - 337
Citations - 32940
Lothar Hennighausen is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Transcription factor & Gene. The author has an hindex of 96, co-authored 316 publications receiving 31267 citations. Previous affiliations of Lothar Hennighausen include Chonnam National University & Dankook University.
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Journal ArticleDOI
Regulated expression of the mouse whey acidic protein gene in transgenic swine
Posted ContentDOI
Interferon-regulated genetic programs and JAK/STAT pathway activate the intronic promoter of the short ACE2 isoform in renal proximal tubules
TL;DR: In this paper, the authors used Human Primary Proximal Tubule (HPPT) cells to show genome-wide gene expression patterns after cytokine stimulation, with emphasis on the ACE2/dACE2 locus.
Posted ContentDOI
Differences in transcriptional response underlie why prior vaccination exceeds prior infection in eliciting robust immune responses in Omicron infected outpatients (preprint)
Hye Kyung Lee,Ludwig Knabl,M. Walter,Yu-Ching Dai,Magdalena Füßl,Yasemin Caf,C. Jeller,Philipp Knabl,M. Obermoser,C. Baurecht,Norbert Kaiser,August Zabernigg,G. M. Wurdinger,Priscilla,A. Marceline van Furth,Lothar Hennighausen +15 more
TL;DR: The early transcriptomic response following Omicron infection in these outpatient populations was investigated and compared it to that found in unvaccinated hospitalized patients with Alpha infection, which showed a gradient of transcriptional response dependent upon prior vaccination and infection status that correlated with disease severity.
Journal ArticleDOI
Limited cross-variant immune response from SARS-CoV-2 Omicron BA.2 in naïve but not previously infected outpatients
TL;DR: This article showed that prior infection status significantly impacts the innate and adaptive immune response against VOC following SARS-CoV-2 Omicron sublineage BA.2 infection.
Journal ArticleDOI
Evaluation of Stat5 as a potential drug target in bcr/abl-induced leukemias
Andrea Hölbl,Christian Schuster,Boris Kovacic,Maria Hölzl,Sabine Fajmann,Florian Grebien,Lothar Hennighausen,Yongzhi Cui,Richard Moriggl,Hartmut Beug,Veronika Sexl +10 more
TL;DR: A key role is defined for Stat5a/b not only for lymphoids development but also for lymphoid transformation, which is necessary for the initial transformation as well as for leukemia progression.