L
Lothar Hennighausen
Researcher at National Institutes of Health
Publications - 337
Citations - 32940
Lothar Hennighausen is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Transcription factor & Gene. The author has an hindex of 96, co-authored 316 publications receiving 31267 citations. Previous affiliations of Lothar Hennighausen include Chonnam National University & Dankook University.
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Stat5 is indispensable for the maintenance of bcr/abl-positive leukaemia.
Andrea Hoelbl,Christian Schuster,Boris Kovacic,Bing-Mei Zhu,Mark C. Wickre,Maria Agnes Hoelzl,Sabine Fajmann,Florian Grebien,Florian Grebien,Wolfgang Warsch,Gabriele Stengl,Lothar Hennighausen,Valeria Poli,Hartmut Beug,Richard Moriggl,Veronika Sexl +15 more
TL;DR: The identification of Stat5 as a vulnerable point in the oncogenic network downstream of Bcr/Abl representing a case of non‐oncogene addiction (NOA) is identified and led to effective elimination of myeloid and lymphoid leukaemia maintenance in vivo.
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EZH2 methyltransferase and H3K27 methylation in breast cancer.
TL;DR: The contribution of EZH2 and the PRC2 complex in controlling the H3K27 methylation status and subsequent consequences on genomic instability and the cell cycle in breast cancer cells are discussed.
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Production of Human Tissue Plasminogen Activator in Transgenic Mouse Milk
TL;DR: In this article, an exogenous gene was expressed in the mammary epithelium of transgenic mice in the hope that the encoded protein would be secreted into milk, and the protein was found to be biologically active.
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Ha-ras oncogene expression directed by a milk protein gene promoter: tissue specificity, hormonal regulation, and tumor induction in transgenic mice.
Anne-Catherine Andres,Cora-Ann Schonenberger,Bernd Groner,Lothar Hennighausen,Marianne LeMeur,Pierre Gerlinger +5 more
TL;DR: In this article, the activation of the activated human Ha-ras oncogene was subjected to the control of the promoter region of the murine whey acidic protein (Wap) gene, which is expressed in mammary epithelial cells in response to lactogenic hormones.
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Hierarchy within the mammary STAT5-driven Wap super-enhancer.
Ha Youn Shin,Michaela Willi,Michaela Willi,Kyung Hyun Yoo,Xianke Zeng,Chaochen Wang,Gil Metser,Lothar Hennighausen +7 more
TL;DR: The identification of mammary-specific super-enhancers and the mechanistic exploration of the Wap locus provide insights into the regulation of cell-type-specific expression of hormone-sensing genes.