L
Lotte Vlam
Researcher at Utrecht University
Publications - 17
Citations - 680
Lotte Vlam is an academic researcher from Utrecht University. The author has contributed to research in topics: Multifocal motor neuropathy & Progressive muscular atrophy. The author has an hindex of 10, co-authored 17 publications receiving 587 citations. Previous affiliations of Lotte Vlam include Radboud University Nijmegen.
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Journal ArticleDOI
Multifocal motor neuropathy: diagnosis, pathogenesis and treatment strategies
Lotte Vlam,W. Ludo van der Pol,Elisabeth A. Cats,Dirk C. G. Straver,Sanneke Piepers,Hessel Franssen,Leonard H. van den Berg +6 more
TL;DR: The diagnostic criteria for MMN is discussed, available treatments and promising new therapeutic strategies are described, and an update on the current understanding of MMN pathogenesis is provided.
Journal ArticleDOI
VCP mutations in familial and sporadic amyotrophic lateral sclerosis
Max Koppers,Marka van Blitterswijk,Lotte Vlam,Paulina A. Rowicka,Paul W.J. van Vught,Ewout J N Groen,Wim G.M. Spliet,Joo-Yeon Engelen-Lee,Helenius J. Schelhaas,Marianne de Visser,Anneke J. van der Kooi,W-Ludo van der Pol,R. Jeroen Pasterkamp,Jan H. Veldink,Leonard H. van den Berg +14 more
TL;DR: Conservation analysis and protein prediction software indicate the p.I114V mutation to be a rare benign polymorphism, which is a rare cause of familial ALS and the role of VCP mutations in sporadic ALS, if present, appears limited.
Journal ArticleDOI
Hexanucleotide repeat expansions in C9ORF72 in the spectrum of motor neuron diseases.
Wouter van Rheenen,Marka van Blitterswijk,Mark H B Huisman,Lotte Vlam,Perry T.C. van Doormaal,Meinie Seelen,Jelena Medic,Dennis Dooijes,Marianne de Visser,Anneke J. van der Kooi,Joost Raaphorst,Helenius J. Schelhaas,W. Ludo van der Pol,Jan H. Veldink,Leonard H. van den Berg +14 more
TL;DR: The hexanucleotide repeat expansion in C9ORF72 is a major cause of fALS and apparently sporadic ALS in the Netherlands and may justify genetic testing in patients with sALS.
Journal ArticleDOI
Genetic overlap between apparently sporadic motor neuron diseases.
Marka van Blitterswijk,Lotte Vlam,Michael A. van Es,W-Ludo van der Pol,Eric A. M. Hennekam,Dennis Dooijes,Helenius J. Schelhaas,Anneke J. van der Kooi,Marianne de Visser,Jan H. Veldink,Leonard H. van den Berg +10 more
TL;DR: A genetic overlap between apparently sporadic PMA and ALS is demonstrated and mutations in genes known to be associated with MNDs are compared.
Journal ArticleDOI
Autoantibody pathogenicity in a multifocal motor neuropathy induced pluripotent stem cell-derived model.
Oliver Harschnitz,Leonard H. van den Berg,Lill Eva Johansen,Marc D. Jansen,Sandra Kling,Renata Vieira de Sá,Lotte Vlam,Wouter van Rheenen,Henk Karst,Corette J. Wierenga,R. Jeroen Pasterkamp,W. Ludo van der Pol +11 more
TL;DR: In this article, the pathogenicity of immunoglobulin M (IgM) anti-GM1 antibodies in serum from patients with multifocal motor neuropathy (MMN) using human induced pluripotent stem cell (iPSC)-derived motor neurons (MNs).