P
Perry T.C. van Doormaal
Researcher at Utrecht University
Publications - 27
Citations - 2076
Perry T.C. van Doormaal is an academic researcher from Utrecht University. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Population. The author has an hindex of 14, co-authored 23 publications receiving 1681 citations. Previous affiliations of Perry T.C. van Doormaal include University Medical Center Utrecht.
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Journal ArticleDOI
Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis
Wouter van Rheenen,Aleksey Shatunov,Annelot M. Dekker,Russell L. McLaughlin,Frank P. Diekstra,Sara L. Pulit,Rick A.A. van der Spek,Urmo Võsa,Simone de Jong,Simone de Jong,Matthew R. Robinson,Jian Yang,Isabella Fogh,Isabella Fogh,Perry T.C. van Doormaal,Gijs H.P. Tazelaar,Max Koppers,Anna M. Blokhuis,William Sproviero,Ashley R. Jones,Kevin P. Kenna,Kristel R. van Eijk,Oliver Harschnitz,Raymond D. Schellevis,William J. Brands,Jelena Medic,Androniki Menelaou,Alice Vajda,Alice Vajda,Nicola Ticozzi,Kuang Lin,Boris Rogelj,Katarina Vrabec,Metka Ravnik-Glavač,Blaž Koritnik,Janez Zidar,Lea Leonardis,Leja Dolenc Grošelj,Stéphanie Millecamps,François Salachas,Vincent Meininger,Mamede de Carvalho,Susana Pinto,Jesus S. Mora,Ricardo Rojas-García,Meraida Polak,Siddharthan Chandran,Shuna Colville,Robert Swingler,Karen E. Morrison,Pamela J. Shaw,John Hardy,Richard W. Orrell,Alan M. Pittman,Katie Sidle,Pietro Fratta,Andrea Malaspina,Simon Topp,Susanne Petri,Susanne Abdulla,Carsten Drepper,Michael Sendtner,Thomas F. Meyer,Roel A. Ophoff,Roel A. Ophoff,Roel A. Ophoff,Kim A. Staats,Martina Wiedau-Pazos,Catherine Lomen-Hoerth,Vivianna M. Van Deerlin,John Q. Trojanowski,Lauren Elman,Leo McCluskey,A. Nazli Basak,Ceren Tunca,Hamid Hamzeiy,Yesim Parman,Thomas Meitinger,Peter Lichtner,Milena Radivojkov-Blagojevic,Christian R. Andres,Cindy Maurel,Gilbert Bensimon,Bernhard Landwehrmeyer,Alexis Brice,Christine Payan,Safaa Saker-Delye,Alexandra Durr,Nicholas W. Wood,Lukas Tittmann,Wolfgang Lieb,Andre Franke,Marcella Rietschel,Sven Cichon,Markus M. Nöthen,Philippe Amouyel,Christophe Tzourio,Jean-François Dartigues,André G. Uitterlinden,Fernando Rivadeneira,Karol Estrada,Albert Hofman,Albert Hofman,Charles Curtis,Charles Curtis,Hylke M. Blauw,Anneke J. van der Kooi,Marianne de Visser,An Goris,Markus Weber,Christopher Shaw,Bradley N. Smith,Orietta Pansarasa,Cristina Cereda,Roberto Del Bo,Giacomo P. Comi,Sandra D'Alfonso,Cinzia Bertolin,Gianni Sorarù,Letizia Mazzini,Viviana Pensato,Cinzia Gellera,Cinzia Tiloca,Antonia Ratti,Andrea Calvo,Cristina Moglia,Maura Brunetti,Simona Arcuti,Rosa Capozzo,Chiara Zecca,Christian Lunetta,Silvana Penco,Nilo Riva,Alessandro Padovani,Massimiliano Filosto,Bernard Muller,Robbert Jan Stuit,Ian P. Blair,Katharine Y. Zhang,Emily P. McCann,Jennifer A. Fifita,Garth A. Nicholson,Garth A. Nicholson,Dominic B. Rowe,Roger Pamphlett,Matthew C. Kiernan,Julian Grosskreutz,Otto W. Witte,Thomas M. Ringer,Tino Prell,Beatrice Stubendorff,Ingo Kurth,Christian A. Hübner,P. Nigel Leigh,Federico Casale,Adriano Chiò,Ettore Beghi,Elisabetta Pupillo,Rosanna Tortelli,Giancarlo Logroscino,John Powell,Albert C. Ludolph,Jochen H. Weishaupt,Wim Robberecht,Philip Van Damme,Lude Franke,Tune H. Pers,Robert H. Brown,Jonathan D. Glass,John Landers,Orla Hardiman,Orla Hardiman,Peter M. Andersen,Peter M. Andersen,Philippe Corcia,Patrick Vourc'h,Vincenzo Silani,Naomi R. Wray,Peter M. Visscher,Paul I.W. de Bakker,Michael A. van Es,R. Jeroen Pasterkamp,Cathryn M. Lewis,Gerome Breen,Gerome Breen,Ammar Al-Chalabi,Leonard H. van den Berg,Jan H. Veldink +187 more
TL;DR: Evidence of ALS being a complex genetic trait with a polygenic architecture is established and the SNP-based heritability is estimated at 8.5%, with a distinct and important role for low-frequency variants (frequency 1–10%).
Journal ArticleDOI
Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis.
Michael A. van Es,Jan H. Veldink,Christiaan G J Saris,Hylke M. Blauw,Paul W.J. van Vught,Anna Birve,Robin Lemmens,Robin Lemmens,Helenius J. Schelhaas,Ewout J N Groen,Mark H B Huisman,Anneke J. van der Kooi,Marianne de Visser,Caroline Dahlberg,Karol Estrada,Fernando Rivadeneira,Albert Hofman,Machiel J. Zwarts,Perry T.C. van Doormaal,Dan Rujescu,Eric Strengman,Ina Giegling,Pierandrea Muglia,Barbara Tomik,Agnieszka Slowik,André G. Uitterlinden,Corinna Hendrich,Stefan Waibel,Thomas F. Meyer,Albert C. Ludolph,Jonathan D. Glass,Shaun Purcell,Sven Cichon,Markus M. Nöthen,H-Erich Wichmann,Stefan Schreiber,Sita H. Vermeulen,Lambertus A. Kiemeney,John H. J. Wokke,Simon Cronin,Simon Cronin,Russell L. McLaughlin,Russell L. McLaughlin,Orla Hardiman,Orla Hardiman,Katsumi Fumoto,R. Jeroen Pasterkamp,Vincent Meininger,Judith Melki,P. Nigel Leigh,Christopher Shaw,John Landers,John Landers,Ammar Al-Chalabi,Robert H. Brown,Robert H. Brown,Wim Robberecht,Wim Robberecht,Peter M. Andersen,Roel A. Ophoff,Roel A. Ophoff,Leonard H. van den Berg +61 more
TL;DR: A genome-wide association study among 2,323 individuals with sporadic amyotrophic lateral sclerosis and 9,013 control subjects and evaluated all SNPs with P < 1.0 × 10−4 revealed genome- wide significance for one SNP, rs12608932, which maps to a haplotype block within the boundaries of UNC13A, which regulates the release of neurotransmitters at neuromuscular synapses.
Journal ArticleDOI
Population based epidemiology of amyotrophic lateral sclerosis using capture–recapture methodology
Mark H B Huisman,Sonja W. de Jong,Perry T.C. van Doormaal,Stephanie S Weinreich,H. Jurgen Schelhaas,Anneke J. van der Kooi,Marianne de Visser,Jan H. Veldink,Leonard H. van den Berg +8 more
TL;DR: The incidence decline in the elderly may suggest that ALS is not merely the result of ageing, and the absence of a significant postmenopausal drop in the male:female ratio suggests that the protective role of female sex hormones in ALS is limited.
Journal ArticleDOI
NEK1 variants confer susceptibility to amyotrophic lateral sclerosis
Kevin P. Kenna,Perry T.C. van Doormaal,Annelot M. Dekker,Nicola Ticozzi,Brendan J. Kenna,Frank P. Diekstra,Wouter van Rheenen,Kristel R van Eijk,Ashley R. Jones,Pamela Keagle,Aleksey Shatunov,William Sproviero,Bradley N. Smith,Michael A van Es,Simon Topp,Aoife Kenna,Jack W. Miller,Claudia Fallini,Cinzia Tiloca,Russell L. McLaughlin,Caroline Vance,Claire Troakes,Claudia Colombrita,Gabriele Mora,Andrea Calvo,Federico Verde,Safa Al-Sarraj,Andrew T. King,Daniela Calini,Jacqueline de Belleroche,Frank Baas,Anneke J. van der Kooi,Marianne de Visser,Anneloor L.M.A. ten Asbroek,Peter C. Sapp,Diane McKenna-Yasek,Meraida Polak,Seneshaw Asress,José Luis Muñoz-Blanco,Tim M. Strom,Thomas Meitinger,Karen E. Morrison,Giuseppe Lauria,Kelly L. Williams,P. Nigel Leigh,Garth A. Nicholson,Garth A. Nicholson,Ian P. Blair,Claire S. Leblond,Patrick A. Dion,Guy A. Rouleau,Hardev Pall,Hardev Pall,Pamela J. Shaw,Martin R Turner,Kevin Talbot,Franco Taroni,Kevin B. Boylan,Marka van Blitterswijk,Rosa Rademakers,Jesús Esteban-Pérez,Alberto García-Redondo,Phillip Van Damme,Wim Robberecht,Adriano Chiò,Cinzia Gellera,Carsten Drepper,Michael Sendtner,Antonia Ratti,Jonathan D. Glass,Jesus S. Mora,Nazli Basak,Orla Hardiman,Albert C. Ludolph,Peter M. Andersen,Jochen H. Weishaupt,Robert H. Brown,Ammar Al-Chalabi,Vincenzo Silani,Christopher Shaw,Leonard H. van den Berg,Jan H. Veldink,John Landers +82 more
TL;DR: In a new screening strategy, gene-burden analyses trained with established ALS genes are performed and a significant association between loss-of-function (LOF) NEK1 variants and FALS risk is identified.
Journal ArticleDOI
Lifetime physical activity and the risk of amyotrophic lateral sclerosis
Mark H B Huisman,Meinie Seelen,Sonja W. de Jong,Kirsten R I S Dorresteijn,Perry T.C. van Doormaal,Anneke J. van der Kooi,Marianne de Visser,Helenius J. Schelhaas,Leonard H. van den Berg,Jan H. Veldink +9 more
TL;DR: An increased risk of ALS with higher levels of leisure time physical activity was found and the lack of association with occupational physical activity and the absence of a dose–response relationship strengthen the hypothesis that not increased physical activity per se but rather a genetic profile or lifestyle promoting physical fitness increases ALS susceptibility.