Lou F. M. H. de Leij

TL;DR: Evidence is presented for a consistent deletion at the chromosomal region 3p21, not only in SCLC11, but in all major types of lung cancer.

TL;DR: The controversial biological role of EpCAM is described with the focus on carcinogenesis: as an adhesion molecule, EpCam mediates homophilic adhesion interactions, which in turn might prevent metastasis, and epigenetic editing is proposed as a novel approach to investigate the biological role.

TL;DR: This review gives a concise overview of studies on the application of cationic liposomes in vivo in animal models of diseases and in clinical studies, and discusses the transfection efficiency, the pharmacokinetic and pharmacodynamic properties of the lipid-DNA complexes, and potentially relevant applications for cationo- DNA complexes.

TL;DR: In EM females compared to EM males, CYP2D6 activity is increased and CyP2C19 activity is reduced, and this reduction is substantial and most pronounced in the age range from 18 to 40 years.

TL;DR: Recent progress and prospects of selected novel anti-cancer approaches that specifically target and sensitize cancer cells to apoptosis are reviewed.