L
Louis Horwitz
Researcher at Johns Hopkins University
Publications - 25
Citations - 681
Louis Horwitz is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Syngeneic Graft & CD8. The author has an hindex of 15, co-authored 25 publications receiving 677 citations.
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Journal ArticleDOI
Development of graft-vs.-host disease-like syndrome in cyclosporine-treated rats after syngeneic bone marrow transplantation. I. Development of cytotoxic T lymphocytes with apparent polyclonal anti-Ia specificity, including autoreactivity.
TL;DR: Results suggested that the anti-class II autoreactive cell associated with syngeneic GVHD either recognizes a common class II determinant ("public" epitope) shared by multiple strains of rats, or was polyspecific with respect to "private" class IIeterminants.
Journal ArticleDOI
C6 produced by macrophages contributes to cardiac allograft rejection.
Zhiping Qian,Barbara A. Wasowska,E Behrens,D. Cangello,Jonathan R. Brody,Shri Hari S. Kadkol,Louis Horwitz,Jinhuan Liu,Charles J. Lowenstein,Allan D. Hess,Fred Sanfilippo,William M. Baldwin +11 more
TL;DR: Results indicate that C6 produced by macrophages can cause significant tissue damage in hearts grafted to hosts after C6 reconstitution by bone marrow transplantation.
Journal Article
Characterization of the autoreactive T cell repertoire in cyclosporin- induced syngeneic graft-versus-host disease: A highly conserved repertoire mediates autoaggression
Anne C. Fischer,Peter P. Ruvolo,Richard K. Burt,Louis Horwitz,Emilie C. Bright,Joellyn M. Hess,William E. Beschorner,Allan D. Hess +7 more
TL;DR: There was a pronounced shift in the expression of this determinant between CD4 and CD8 single positive thymocytes, suggesting that CsA may inhibit normal positive selection processes for MHC class I and class II reactive T cells.
Journal Article
Characterization of peripheral autoregulatory mechanisms that prevent development of cyclosporin-induced syngeneic graft-versus-host disease.
TL;DR: The studies reveal that although cyclosporin did not interfere with the effector function of the autoregulatory T cells, it prevented the reconstitution of the regulatory system after syngeneic bone marrow transplantation.
Journal ArticleDOI
Promiscuous recognition of major histocompatibility complex class II determinants in cyclosporine-induced syngeneic graft-versus-host disease: specificity of cytolytic effector T cells.
TL;DR: The results suggest that recognition of this highly conserved peptide along with the additional interaction between the flanking region and the T cell receptor may account for the promiscuous activity of the autologous/syngeneic GVHD autoreactive T cells.