L
Louis R. Lapierre
Researcher at Brown University
Publications - 36
Citations - 7354
Louis R. Lapierre is an academic researcher from Brown University. The author has contributed to research in topics: Autophagy & Biology. The author has an hindex of 18, co-authored 29 publications receiving 6397 citations. Previous affiliations of Louis R. Lapierre include Sanford-Burnham Institute for Medical Research & Dalhousie University.
Papers
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Lipid droplets modulate proteostasis, SQST-1/SQSTM1 dynamics, and lifespan in C. elegans
Anita Kumar,Joslyn Mills,Wesley Parker,Joshua A. Leitão,Celeste Ng,Rishi Patel,Joseph Aguilera,Joseph R Johnson,Shi Quan Wong,Louis R. Lapierre +9 more
TL;DR: A key role is uncovered for lipid droplets in C. elegans as a proteostatic mediator that reduces protein ubiquitination, facilitates autophagy, and promotes longevity.
Patent
Nucleocytoplasmic regulator of autophagy-associated transcription factors
TL;DR: In this paper, compositions and methods of treatment for neurodegenerative diseases associated with aging and methods for increasing longevity by inhibiting the expression of the protein exportin-1 (XPO1, CRM-1 or karyopherin) or a fragment thereof are presented.
Posted ContentDOI
AltumAge: A Pan-Tissue DNA-Methylation Epigenetic Clock Based on Deep Learning
TL;DR: AltumAge as mentioned in this paper used deep learning interpretation methods to learn which methylation sites contributed to the final model predictions and found that the CpG sites with the highest contribution to the model predictions were related to heterochromatin and gene regulatory regions in the genome.
Posted ContentDOI
Neuronal HLH-30/TFEB modulates muscle mitochondrial fragmentation to improve thermoresistance in C. elegans
TL;DR: This study uncovers a novel mechanism of heat stress protection mediated by neuronal HLH-30/TFEB, a conserved master transcriptional activator of autophagy and lysosomal genes that modulates organismal lifespan regulation and stress resistance.
Posted ContentDOI
Improving epigenetic clock performance and interpretation with deep learning
TL;DR: AltumAge as mentioned in this paper is a neural network-based approach for age prediction based on DNA methylation, which is more generalizable in older ages and new tissue types than regularized linear regression.