L
Louis R. Lapierre
Researcher at Brown University
Publications - 36
Citations - 7354
Louis R. Lapierre is an academic researcher from Brown University. The author has contributed to research in topics: Autophagy & Biology. The author has an hindex of 18, co-authored 29 publications receiving 6397 citations. Previous affiliations of Louis R. Lapierre include Sanford-Burnham Institute for Medical Research & Dalhousie University.
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Journal ArticleDOI
Reduced ech-6 expression attenuates fat-induced lifespan shortening in C. elegans
Yasmine J. Liu,Arwen W. Gao,Reuben L. Smith,Georges E. Janssens,Daan M. Panneman,Aldo Jongejan,Michel van Weeghel,Frédéric M. Vaz,Melissa J. Silvestrini,Louis R. Lapierre,Alyson W. MacInnes,Riekelt H. Houtkooper +11 more
TL;DR: In this paper , the expression of the gene ech-6 encoding enoyl-CoA hydratase remitted fat diet-induced deleterious effects on lifespan in Caenorhabditis elegans, while a basal expression of ech6 was important for survival under normal dietary conditions.
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Regulation of hepatic production of lipoproteins containing apolipoprotein B by ER-associated degradation
TL;DR: The LDL receptor is central to the understanding of LDL clearance from the plasma compartment and emerging evidence suggests that hepatic overproduction of very low-density lipoproteins (VLDL) is also an important contributor to metabolic dyslipidemic states with increased cardiovascular disease risk.
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Exportin 1 modulates life span by regulating nucleolar dynamics via the autophagy protein LGG-1/GABARAP.
Anita Kumar,Taewook Kang,Tara Thakurta,Celeste Ng,Aric N. Rogers,Martin R. Larsen,Louis R. Lapierre +6 more
TL;DR: Using transcriptomic and subcellular proteomic analyses in nematodes, it is demonstrated that XPO-1 modulates the nucleocytoplasmic distribution of key proteins involved in nucleolar dynamics and ribosome function, including fibrillarin and RPL-11.
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Transitin is required for the differentiation of avian QM7 myoblasts into myotubes
Maroua Jalouli,Louis R. Lapierre,Dominique Guérette,Karine Blais,Ju-Ahng Lee,Gregory J. Cole,Michel Vincent +6 more
TL;DR: Observations indicate that transitin plays an important role in the initiation of the myogenic program in avian muscle progenitor cells in acting downstream of MyoD and upstream of myogenin during the lineage progression.
Journal ArticleDOI
Location, location, location: subcellular protein partitioning in proteostasis and aging
Anita Kumar,Louis R. Lapierre +1 more
TL;DR: In this article, the authors review recent literature related to nucleocytoplasmic partitioning of proteins, nuclear and cytoplasic quality control mechanisms, and their impact on the development of age-related diseases.