L
Louis Schofield
Researcher at New York University
Publications - 5
Citations - 1262
Louis Schofield is an academic researcher from New York University. The author has contributed to research in topics: Interferon gamma & Plasmodium berghei. The author has an hindex of 4, co-authored 5 publications receiving 1224 citations.
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Journal ArticleDOI
γ Interferon, CD8 + T cells and antibodies required for immunity to malaria sporozoites
Louis Schofield,Jaime Villaquiran,Arturo Ferreira,H. Schellekens,Ruth S. Nussenzweig,Victor Nussenzweig +5 more
TL;DR: Surgical immunity to sporozoite challenge requires the neutralization of sporozoites by antibodies and the inhibition of EEF development by γIFN with the participation of CD8+ cells, and transfer of both immune components resulted in significantly greater protection.
Journal ArticleDOI
Inhibition of development of exoerythrocytic forms of malaria parasites by gamma-interferon
Arturo Ferreira,Louis Schofield,Vincenzo Enea,Huub Schellekens,P van der Meide,William E. Collins,Ruth S. Nussenzweig,V Nussenzweig +7 more
TL;DR: Results suggest that immunologically induced interferon may be involved in controlling malaria infection under natural conditions.
Journal Article
Interferon-gamma inhibits the intrahepatocytic development of malaria parasites in vitro.
TL;DR: The activity of recombinant interferon (IFN)-gamma against Plasmodium berghei exoerythrocytic forms (EEF) grown in vitro within the highly differentiated human hepatoma cell line HEPG2 supports the view that IFN-gamma exerts its antimalarial activity by binding to surface receptors on hepatocytes and inducing intracellular changes unfavorable for parasite development.
Journal ArticleDOI
The 140/130/105 kilodalton protein complex in the rhoptries of Plasmodium falciparum consists of discrete polypeptides.
Juan A. Cooper,L. T. Ingram,Gillian Robin Bushell,Cathy A. Fardoulys,D. J. Stenzel,Louis Schofield,Allan Saul +6 more
TL;DR: Four monoclonal antibodies recognise an antigen localised in the rhoptries of Plasmodium falciparum merozoites using both indirect immunofluorescence assay and immunoelectron microscopy with immunogold labeling.