V
Victor Nussenzweig
Researcher at New York University
Publications - 221
Citations - 20528
Victor Nussenzweig is an academic researcher from New York University. The author has contributed to research in topics: Circumsporozoite protein & Antigen. The author has an hindex of 69, co-authored 221 publications receiving 19963 citations. Previous affiliations of Victor Nussenzweig include Johns Hopkins University School of Medicine & National Institutes of Health.
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A population of lymphocytes bearing a membrane receptor for antigen-antibody-complement complexes. I. Separation and characterization.
TL;DR: A population of lymphoid cells from several animal species, including man, was identified through a membrane receptor which binds sheep red blood cells treated with antibody and complement, and these cells could be distinguished by their different abilities to bind EAC, CRL and non-CRL from mouse lymphoid organs.
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γ Interferon, CD8 + T cells and antibodies required for immunity to malaria sporozoites
Louis Schofield,Jaime Villaquiran,Arturo Ferreira,H. Schellekens,Ruth S. Nussenzweig,Victor Nussenzweig +5 more
TL;DR: Surgical immunity to sporozoite challenge requires the neutralization of sporozoites by antibodies and the inhibition of EEF development by γIFN with the participation of CD8+ cells, and transfer of both immune components resulted in significantly greater protection.
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TRAP is necessary for gliding motility and infectivity of plasmodium sporozoites.
Ali A. Sultan,Vandana Thathy,Ute Frevert,Kathryn J. H. Robson,Andrea Crisanti,Victor Nussenzweig,Ruth S. Nussenzweig,Robert Ménard +7 more
TL;DR: It is demonstrated that by gene targeting in a rodent Plasmodium, TRAP is critical for sporozoite infection of the mosquito salivary glands and the rat liver, and is essential for sporzoite gliding motility in vitro, suggesting that in PlasModium sporozoites, and likely in other Apicomplexa, gliding locomotion and cell invasion have a common molecular basis.
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Receptors for complement on leukocytes
TL;DR: When C' factors from mouse serum are added to the antigen-19S antibody complex (EAC'), rosettes are formed on most mouse peritoneal macrophages and PMN and on a few monocytes, and EAC' also adheres to 10–25% of lymph node lymphocytes but not to thymus lymphocytes.
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Migration of Plasmodium Sporozoites Through Cells Before Infection
Maria M. Mota,Gabriele Pradel,Jerome P. Vanderberg,Julius C. R. Hafalla,Ute Frevert,Ruth S. Nussenzweig,Victor Nussenzweig,Ana Rodriguez +7 more
TL;DR: Sporozoite migration through several cells in the mammalian host appears to be essential for the completion of the life cycle of Plasmodium sporozoites.