L
Louise A. Knight
Researcher at Queen Alexandra Hospital
Publications - 24
Citations - 708
Louise A. Knight is an academic researcher from Queen Alexandra Hospital. The author has contributed to research in topics: Chemosensitivity assay & Cisplatin. The author has an hindex of 16, co-authored 24 publications receiving 663 citations. Previous affiliations of Louise A. Knight include University of Portsmouth.
Papers
More filters
Journal Article
Chemosensitization of solid tumors by modulation of resistance mechanisms.
TL;DR: Oncologists should take account of potential resistance mechanisms when treating patients: it is often feasible to design combinations with old or new drugs which exploit these apparent weaknesses to the patient's advantage.
Journal Article
Chemosensitization of solid tumor cells by alteration of their susceptibility to apoptosis.
TL;DR: Alteration of the susceptibility of cancer cells to apoptosis, the process of individual cell death by which many chemotherapeutic drugs act, shows particular promise for therapy in the future, and is the focus of this review.
Journal ArticleDOI
Use of an ATP-based chemosensitivity assay to design new combinations of high-concentration doxorubicin with other drugs for recurrent ovarian cancer.
Federica Di Nicolantonio,Michael H Neale,Louise A. Knight,Alan Lamont,Geraldine E Skailes,Richard J Osborne,Rosanne Allerton,Christian M. Kurbacher,Ian A. Cree +8 more
TL;DR: An ATP-based tumor chemosensitivity assay is used to determine the relative efficacy of high concentrations of doxorubicin tested in combination with cisplatin, treosulfan, 5-fluorouracil (5-FU) or vinorelbine against cells obtained from recurrent ovarian tumor tissue.
Journal ArticleDOI
The effect of imatinib mesylate (Glivec) on human tumor-derived cells.
Louise A. Knight,Federica Di Nicolantonio,Pauline A. Whitehouse,Stuart Mercer,Sanjay Sharma,Sharon Glaysher,John L. Hungerford,Jeremy Hurren,Alan Lamont,Ian A. Cree +9 more
TL;DR: The signaling pathways mediated by activation of c-kit or platelet-derived growth factor receptor may act as antiapoptotic survival signals in some cancers and inhibition of these pathways may potentiate the activity of some cytotoxic drugs by inhibiting the survival signal.
Book ChapterDOI
Quality assurance and good laboratory practice.
Louise A. Knight,Ian A. Cree +1 more
TL;DR: This chapter provides a brief and practical outline of the steps needed to mitigate the risks associated with poor cell culture practice.