Michael H Neale

TL;DR: It is shown that the Hect (homologous to the E6-associated protein C terminus)-containing Nedd4-like ubiquitin protein ligase Itch binds, ubiquitylates, and promotes the degradation of p63, suggesting that Itch has a fundamental role in the mechanism that controls endogenous p63 protein levels and therefore contributes to regulation of p 63 in physiological conditions.

TL;DR: Though limited in number, the highest VEGF levels correlated with previous radiation therapy, and with the presence neovascularisation of the iris or optic nerve head, these data suggest that anti-VEGF therapy might prove useful in the management of some patients with NVI secondary to uveal melanoma.

TL;DR: The finding of improved rather than reduced survival in inc- myc positive tumours is at variance with skin melanoma, and there was no evidence to suggest that c-myc was modulated by upregulation ofBcl-2 or p53inactivation/mutation.

TL;DR: It is shown that p73α, -β, and -γ bind to the protein inhibitor of activated STAT-1 (PIAS-1) and that this binding stabilizes p73, and that PIas-1-mediated sumoylation decreases p73 transcriptional activity on several target promoters, such as Bax.

TL;DR: The combination of treosulfan with gemcitabine or cytosine arabinoside shows activity ex vivo against primary tumour tissue in choroidal melanoma patients.