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Louise A. Knight
Researcher at Queen Alexandra Hospital
Publications - 24
Citations - 708
Louise A. Knight is an academic researcher from Queen Alexandra Hospital. The author has contributed to research in topics: Chemosensitivity assay & Cisplatin. The author has an hindex of 16, co-authored 24 publications receiving 663 citations. Previous affiliations of Louise A. Knight include University of Portsmouth.
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Journal ArticleDOI
Resistance gene expression determines the in vitro chemosensitivity of non-small cell lung cancer (NSCLC)
Sharon Glaysher,Dennis Yiannakis,Francis G Gabriel,Penny Johnson,Marta E Polak,Louise A. Knight,Zoe Goldthorpe,Katharine Peregrin,Mya Gyi,Paul Modi,Joe Rahamim,Mark E F Smith,Khalid Amer,Bruce J. Addis,Matthew Poole,Ajit Narayanan,Tim J. Gulliford,Peter E. Andreotti,Ian A. Cree +18 more
TL;DR: Genes predicted to be involved in known mechanisms drug sensitivity and resistance correlate well with in vitro chemosensitivity and may allow the definition of predictive signatures to guide individualized chemotherapy in lung cancer.
Journal ArticleDOI
Activity of mevalonate pathway inhibitors against breast and ovarian cancers in the ATP-based tumour chemosensitivity assay.
Louise A. Knight,Christian M. Kurbacher,Sharon Glaysher,Augusta Fernando,Ralf Reichelt,Susanne Dexel,Uwe Reinhold,Ian A. Cree +7 more
TL;DR: The combination of zoledronic acid and fluvastatin may have activity against breast and ovarian cancer based on direct anti-cancer cell effects, and a clinical trial to test this is in preparation.
Journal ArticleDOI
The molecular basis of the chemosensitivity of metastatic cutaneous melanoma to chemotherapy
Katharine A. Parker,Sharon Glaysher,Marta E Polak,Francis G Gabriel,Penny Johnson,Louise A. Knight,Matthew Poole,Ajit Narayanan,Jeremy Hurren,Ian A. Cree +9 more
TL;DR: Data suggest that melanoma chemosensitivity is influenced by known resistance mechanisms, including susceptibility to apoptosis, which may increase understanding of the mechanisms underlying chemos sensitivity to drugs active against melanoma and provide signatures with predictive value.
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The effect of tricyclic antidepressants on cutaneous melanoma cell lines and primary cell cultures.
Katharine A. Parker,Sharon Glaysher,Jeremy Hurren,Louise A. Knight,Deidre McCormick,Anne Suovouri,Verena Amberger-Murphy,Geoffrey J. Pilkington,Ian A. Cree +8 more
TL;DR: A study in primary cell cultures from metastatic cutaneous melanoma deposits using a well established ATP-based tumour chemosensitivity assay to confirm and extend findings of tricyclic antidepressants against glioma cells.
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Pilot studies of the effect of zoledronic acid (Zometa) on tumor-derived cells ex vivo in the ATP-based tumor chemosensitivity assay.
Louise A. Knight,Mark Conroy,Augusta Fernando,Marta E Polak,Christian M. Kurbacher,Ian A. Cree +5 more
TL;DR: A direct, or possibly an indirect, effect of zoledronic acid and other nitrogen-containing bisphosphonates against neoplastic cells, but simultaneous addition with cisplatin or paclitaxel does not substantially increase the activity of the cytotoxic agent.