L
Lu Chen
Researcher at National Institutes of Health
Publications - 60
Citations - 2579
Lu Chen is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cancer & In vivo. The author has an hindex of 17, co-authored 53 publications receiving 1679 citations. Previous affiliations of Lu Chen include University of Texas System & University of Texas MD Anderson Cancer Center.
Papers
More filters
Journal ArticleDOI
Effect of KRAS Oncogene Substitutions on Protein Behavior: Implications for Signaling and Clinical Outcome
Nathan T. Ihle,Lauren Averett Byers,Edward S. Kim,Pierre Saintigny,J. Jack Lee,George R. Blumenschein,Anne Tsao,Suyu Liu,Jill E. Larsen,Jing Wang,Lixia Diao,Kevin R. Coombes,Lu Chen,Shuxing Zhang,Mena Abdelmelek,Ximing Tang,Vassiliki A. Papadimitrakopoulou,John D. Minna,Scott M. Lippman,Waun Ki Hong,Roy S. Herbst,Ignacio I. Wistuba,John V. Heymach,Garth Powis +23 more
TL;DR: Molecular modeling studies showed that different conformations imposed by mutant KRas may lead to altered association with downstream signaling transducers, and implies that therapeutic interventions may need to take into account the specific mutants expressed by the tumor.
Journal ArticleDOI
Inhibition of B Cell Receptor Signaling by Ibrutinib in Primary CNS Lymphoma
Michail S. Lionakis,Kieron Dunleavy,Mark Roschewski,Brigitte C. Widemann,John A. Butman,Roland Schmitz,Yandan Yang,Diane E. Cole,Christopher Melani,Christine Higham,Jigar V. Desai,Michele Ceribelli,Lu Chen,Craig J. Thomas,Richard F. Little,Juan Gea-Banacloche,Sucharita Bhaumik,Maryalice Stetler-Stevenson,Stefania Pittaluga,Elaine S. Jaffe,John D. Heiss,Nicole Lucas,Seth M. Steinberg,Louis M. Staudt,Wyndham H. Wilson +24 more
TL;DR: Increased aspergillosis was observed with ibrutinib monotherapy and DA-TEDDi-R, and it was linked to BTK-dependent fungal immunity in a murine model and appears to enhance the efficacy of chemotherapy.
Journal ArticleDOI
A multiprotein supercomplex controlling oncogenic signalling in lymphoma
James D. Phelan,Ryan M. Young,Dan E. Webster,Sandrine Roulland,Sandrine Roulland,George E. Wright,Monica Kasbekar,Arthur L. Shaffer,Michele Ceribelli,James Q. Wang,Roland Schmitz,Masao Nakagawa,Emmanuel Bachy,Da-Wei Huang,Yanlong Ji,Lu Chen,Yandan Yang,Hong Zhao,Xin Yu,Weihong Xu,Maryknoll Palisoc,Racquel R. Valadez,Theresa Davies-Hill,Wyndham H. Wilson,Wing C. Chan,Elaine S. Jaffe,Randy D. Gascoyne,Elias Campo,Andreas Rosenwald,German Ott,Jan Delabie,Lisa M. Rimsza,Fausto J. Rodriguez,Fayez Estephan,Matthias Holdhoff,Michael J. Kruhlak,Stephen M. Hewitt,Craig J. Thomas,Stefania Pittaluga,Thomas Oellerich,Thomas Oellerich,Thomas Oellerich,Louis M. Staudt +42 more
TL;DR: A new mode of oncogenic BCR signalling is discovered in ibrutinib-responsive cell lines and biopsies, coordinated by a multiprotein supercomplex formed by MYD88, TLR9 and the BCR (hereafter termed the My-T-BCR supercomplex).
Journal ArticleDOI
Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro
Qi Zhang,Catherine Z. Chen,Manju Swaroop,Miao Xu,Lihui Wang,Juhyung Lee,Amy Wang,Manisha Pradhan,Natalie Hagen,Lu Chen,Min Shen,Zhiji Luo,Xin Xu,Yue Xu,Wenwei Huang,Wei Zheng,Yihong Ye +16 more
TL;DR: HS is established as an attachment factor that assists SARS coronavirus cell entry and reveals drugs capable of targeting this important step in the viral life cycle.
Journal ArticleDOI
Targeting microRNAs with small molecules: from dream to reality
TL;DR: In this article, a novel idea involving the use of small molecules to target overexpressed miRNAs as a new therapy for diseases, particularly cancer, in humans was proposed.