L
Lu Yu
Researcher at Institute of Cancer Research
Publications - 76
Citations - 4599
Lu Yu is an academic researcher from Institute of Cancer Research. The author has contributed to research in topics: Ubiquitin & Citrobacter rodentium. The author has an hindex of 29, co-authored 74 publications receiving 3882 citations. Previous affiliations of Lu Yu include GlaxoSmithKline & Wellcome Trust Sanger Institute.
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Journal ArticleDOI
Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteome.
Mark O. Collins,Holger Husi,Lu Yu,Julia M. Brandon,Christopher N. G. Anderson,Walter P. Blackstock,Walter P. Blackstock,Jyoti S. Choudhary,Seth G. N. Grant +8 more
TL;DR: These synapse proteome data sets offer a basis for future research in synaptic biology and will provide useful information in brain disease and mental disorder studies.
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Accurate and Sensitive Peptide Identification with Mascot Percolator
TL;DR: A software package that interfaces Mascot with Percolator, a well performing machine learning method for rescoring database search results, is presented and it is demonstrated to be amenable for both low and high accuracy mass spectrometry data.
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An Expanded Oct4 Interaction Network: Implications for Stem Cell Biology, Development, and Disease
Mercedes Pardo,Benjamin Lang,Lu Yu,Haydn M. Prosser,Allan Bradley,M. Madan Babu,Jyoti S. Choudhary +6 more
TL;DR: The Oct4 interactome provides a resource for dissecting mechanisms of Oct4 function, enlightening the basis of pluripotency and development, and identifying potential additional reprogramming factors.
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Proteomic Analysis of in Vivo Phosphorylated Synaptic Proteins
Mark O. Collins,Mark O. Collins,Lu Yu,Marcelo P. Coba,Holger Husi,Iain Campuzano,Walter P. Blackstock,Jyoti S. Choudhary,Seth G. N. Grant,Seth G. N. Grant +9 more
TL;DR: Bioinformatic and in vitro phosphorylation assays of peptide arrays suggest that a small number of kinases phosphorylate many proteins and that each substrate is phosphorylated by many kinases, which support a model where the synapse phosphoproteome is functionally organized into a highly interconnected signaling network.
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Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotency
Wee-Wei Tee,Mercedes Pardo,Thorold W. Theunissen,Lu Yu,Jyoti S. Choudhary,Petra Hajkova,M. Azim Surani +6 more
TL;DR: It is shown that loss of Prmt 5 function is early embryonic-lethal due to the abrogation of pluripotent cells in blastocysts, indicating the significance of the Prmt5/Mep50 complex for pluripotency, which may occur in conjunction with the leukemia inhibitory factor (LIF)/Stat3 pathway.