Lubna Al-Khalili

TL;DR: IL-6 increases glycogen synthesis via a PI3-kinase-dependent mechanism and enhances lipid oxidation via an AMPK- dependent mechanism in skeletal muscle.

TL;DR: SiRNA was utilized to decipher the specific role of predominant insulin receptor substrates and Akt isoforms expressed in human skeletal muscle and revealed specialized roles of insulin signaling cascades to metabolic endpoints.

TL;DR: This study confirmed that incubation of primary cultured human muscle cells with GW501516 induced AMPK phosphorylation and increased fatty acid transport and oxidation and glucose uptake and demonstrated that PPARδ expression is required for the effect of GW 501516 on the intracellular accumulation of fatty acids.

TL;DR: It is demonstrated that insulin-stimulated glucose transport in cultured human skeletal muscle is mediated by GLUT4, as no effect on GLUT1 appearance at the plasma membrane was noted and cultured myotubes are a useful tool to facilitate biological and molecular validation of novel pharmacological agents aimed to improve glucose metabolism in skeletal muscle.

TL;DR: Evidence is provided to suggest that PPARdelta agonists increase glucose metabolism and promote gene regulatory responses in cultured human skeletal muscle and provide biological validation of PPardelta as a potential target for antidiabetic therapy.