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Alexander V. Chibalin
Researcher at Karolinska Institutet
Publications - 141
Citations - 8472
Alexander V. Chibalin is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Skeletal muscle & Phosphorylation. The author has an hindex of 52, co-authored 136 publications receiving 7752 citations. Previous affiliations of Alexander V. Chibalin include Tomsk State University.
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Journal ArticleDOI
Exercise intensity-dependent regulation of peroxisome proliferator-activated receptor coactivator-1 mRNA abundance is associated with differential activation of upstream signalling kinases in human skeletal muscle.
Brendan Egan,Brian P. Carson,Pablo M. Garcia-Roves,Alexander V. Chibalin,Fiona M. Sarsfield,Niall Barron,Noel McCaffrey,Niall M. Moyna,Juleen R. Zierath,Donal J. O’Gorman +9 more
TL;DR: In conclusion, exercise intensity regulates PGC‐1α mRNA abundance in human skeletal muscle in response to a single bout of exercise, mediated by differential activation of multiple signalling pathways, with ATF‐2 and HDAC phosphorylation proposed as key intensity‐dependent mediators.
Journal ArticleDOI
Early signaling responses to divergent exercise stimuli in skeletal muscle from well-trained humans
Vernon G. Coffey,Zhihui Zhong,Anthony J. Shield,Benedict J. Canny,Alexander V. Chibalin,Juleen R. Zierath,John A. Hawley +6 more
TL;DR: A degree of “response plasticity” is conserved at opposite ends of the endurance‐hypertrophic adaptation continuum and prior training attenuates the exercise specific signaling responses involved in single mode adaptations to training.
Journal ArticleDOI
Branched-chain amino acids increase p70S6k phosphorylation in human skeletal muscle after resistance exercise.
Håkan Karlsson,Per-Anders Nilsson,Johnny Nilsson,Alexander V. Chibalin,Juleen R. Zierath,Eva Blomstrand +5 more
TL;DR: BCAA, ingested during and after resistance exercise, mediate signal transduction through p70(S6k) in skeletal muscle during exercise and throughout recovery after exercise (2 h postexercise), whereas no change was noted after the placebo trial.
Journal ArticleDOI
Divergent effects of exercise on metabolic and mitogenic signaling pathways in human skeletal muscle
Ulrika Widegren,Xin Jian Jiang,Anna Krook,Alexander V. Chibalin,Marie Björnholm,Michael Tally,Richard A. Roth,Jan Henriksson,Harriet Wallberg-Henriksson,Juleen R. Zierath +9 more
TL;DR: The data do not support a role of Akt or PYK2 in exercise/contraction‐induced signaling in human skeletal muscle, and exercise has divergent effects on parallel MAP kinase pathways, of which only p38 demonstrated a systemic response.
Journal ArticleDOI
AMPK-Mediated AS160 Phosphorylation in Skeletal Muscle Is Dependent on AMPK Catalytic and Regulatory Subunits
Jonas T. Treebak,Stephan Glund,Atul S. Deshmukh,Ditte Kjærsgaard Klein,Yun Chau Long,Thomas E. Jensen,Sebastian Beck Jørgensen,Benoit Viollet,Leif Andersson,Dietbert Neumann,Theo Wallimann,Erik A. Richter,Alexander V. Chibalin,Juleen R. Zierath,Jørgen F. P. Wojtaszewski +14 more
TL;DR: It is shown that AICAR increases AMPK, acetyl-CoA carboxylase, and AS160 phosphorylation by insulin-independent mechanisms in isolated skeletal muscle and implicate AS160 as a downstream target of AMPK.