L
Luc Buée
Researcher at university of lille
Publications - 386
Citations - 25565
Luc Buée is an academic researcher from university of lille. The author has contributed to research in topics: Tau protein & Alzheimer's disease. The author has an hindex of 76, co-authored 351 publications receiving 21497 citations. Previous affiliations of Luc Buée include Lille University of Science and Technology & Innogenetics.
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Journal ArticleDOI
Tau protein isoforms, phosphorylation and role in neurodegenerative disorders
TL;DR: Tau proteins are the major constituents of intraneuronal and glial fibrillar lesions described in Alzheimer's disease and numerous neurodegenerative disorders referred as 'tauopathies' as discussed by the authors.
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Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1
Karen Duff,Karen Duff,Chris Eckman,Cindy Zehr,Cindy Zehr,Xin Yu,Cristian-Mihail Prada,Jordi Pérez-Tur,Jordi Pérez-Tur,Mike Hutton,Mike Hutton,Luc Buée,Yasuo Harigaya,Debra Yager,David G. Morgan,Marcia N. Gordon,Leigh A. Holcomb,Lawrence M. Refolo,Brenda Zenk,John Hardy,John Hardy,Steven G. Younkin +21 more
TL;DR: Results indicate that the presenilin mutations probably cause Alzheimer's disease through a gain of deleterious function that increases the amount of Aβ42(43) in the brain.
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The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer’s disease
André Delacourte,Jean-Philippe David,Nicolas Sergeant,Luc Buée,A. Wattez,Patrick Vermersch,F. Ghozali,Catherine Fallet-Bianco,Florence Pasquier,Florence Lebert,Henri Petit,C. Di Menza +11 more
TL;DR: The relationship between NFD and Alzheimer-type dementia, and the criteria for a biochemical diagnosis of AD, are documented, and an association between AD and the extent of NFD in defined brain areas is shown.
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NLRP3 inflammasome activation drives tau pathology
Christina Ising,Carmen Venegas,Shuangshuang Zhang,Hannah Scheiblich,Susanne V. Schmidt,Ana Vieira-Saecker,Stephanie Schwartz,Shadi Albasset,Róisín M. McManus,Dario Tejera,Angelika Griep,Francesco Santarelli,Frederic Brosseron,Sabine Opitz,James Stunden,Maximilian Merten,Rakez Kayed,Douglas T. Golenbock,David Blum,Eicke Latz,Eicke Latz,Eicke Latz,Luc Buée,Michael T. Heneka,Michael T. Heneka +24 more
TL;DR: An important role of microglia and NLRP3 inflammasome activation in the pathogenesis of tauopathies is identified and the amyloid-cascade hypothesis in Alzheimer’s disease is supported, demonstrating that neurofibrillary tangles develop downstream of amyloids-beta-induced microglial activation.
Journal ArticleDOI
Elevated circulating tumor necrosis factor levels in Alzheimer's disease.
Howard Fillit,Wanhong Ding,Luc Buée,Jill Kalman,Larry Altstiel,Brian A. Lawlor,Giselle Wolf-Klein +6 more
TL;DR: Elevated circulating TNF may be derived from the local CNS inflammatory reaction in AD, and may account for some systemic manifestations of AD such as weight loss.