N
Nicolas Sergeant
Researcher at university of lille
Publications - 35
Citations - 2700
Nicolas Sergeant is an academic researcher from university of lille. The author has contributed to research in topics: Myotonic dystrophy & Tau protein. The author has an hindex of 17, co-authored 35 publications receiving 2342 citations.
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Journal ArticleDOI
The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer’s disease
André Delacourte,Jean-Philippe David,Nicolas Sergeant,Luc Buée,A. Wattez,Patrick Vermersch,F. Ghozali,Catherine Fallet-Bianco,Florence Pasquier,Florence Lebert,Henri Petit,C. Di Menza +11 more
TL;DR: The relationship between NFD and Alzheimer-type dementia, and the criteria for a biochemical diagnosis of AD, are documented, and an association between AD and the extent of NFD in defined brain areas is shown.
Journal ArticleDOI
Biochemistry of Tau in Alzheimer’s disease and related neurological disorders
Nicolas Sergeant,Alexis Bretteville,Malika Hamdane,Marie-Laure Caillet-Boudin,Pierre Grognet,Stéphanie Bombois,David Blum,André Delacourte,Florence Pasquier,Eugeen Vanmechelen,Susanna Schraen-Maschke,Luc Buée +11 more
TL;DR: The main contributions of several proteomic methods in the understanding of Tau, including expression, post-translational modifications and structure, in both physiological and pathophysiological aspects are summarized.
Journal ArticleDOI
Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies.
Valérie Vingtdeux,Malika Hamdane,Anne Loyens,Patrick Gelé,Hervé Drobeck,Séverine Bégard,Marie-Christine Galas,André Delacourte,Jean-Claude Beauvillain,Luc Buée,Nicolas Sergeant +10 more
TL;DR: The data show that multivesicular bodies are essential organelles for APP metabolism and that all APP metabolites can be secreted in the extracellular space.
Journal ArticleDOI
Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer's disease.
André Delacourte,Nicolas Sergeant,Danie Champain,A. Wattez,Claude-Alain Maurage,Florence Lebert,Florence Pasquier,Jean-Philippe David +7 more
TL;DR: The spatial mismatch between amyloid ß-precursor protein (APP) and tau pathologies in cortical brain areas demonstrates that neurodegeneration is not a direct consequence of extracellular A&bgr; neurotoxicity, and should be the main target for the early biological diagnosis of AD and modeling.
Journal ArticleDOI
Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology.
Karim Belarbi,Sylvie Burnouf,Francisco-Jose Fernandez-Gomez,Cyril Laurent,Sophie Lestavel,Martin Figeac,Audrey Sultan,Laetitia Troquier,Antoine Leboucher,Raphaëlle Caillierez,Marie-Eve Grosjean,Dominique Demeyer,Hélène Obriot,I. Brion,B. Barbot,Marie-Christine Galas,Bart Staels,Sandrine Humez,Nicolas Sergeant,Susanna Schraen-Maschke,Anne Muhr-Tailleux,Malika Hamdane,Luc Buée,David Blum +23 more
TL;DR: The data support the view that long-term voluntary physical exercise is an effective strategy capable of mitigating Tau pathology and its pathophysiological consequences, and prevent memory alterations in THY-Tau22 mice.