L
Luca A. Petruccelli
Researcher at McGill University
Publications - 10
Citations - 772
Luca A. Petruccelli is an academic researcher from McGill University. The author has contributed to research in topics: DNA damage & Apoptosis. The author has an hindex of 9, co-authored 10 publications receiving 650 citations. Previous affiliations of Luca A. Petruccelli include Jewish General Hospital.
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Journal ArticleDOI
Metformin Reduces Endogenous Reactive Oxygen Species and Associated DNA Damage
Carolyn Algire,Olga Moiseeva,Xavier Deschênes-Simard,Lilian Amrein,Luca A. Petruccelli,Elena Birman,Benoit Viollet,Gerardo Ferbeyre,Michael Pollak +8 more
TL;DR: It is shown that metformin attenuates paraquat-induced elevations in reactive oxygen species (ROS), and related DNA damage and mutations, but has no effect on similar changes induced by H202, indicating a reduction in endogenous ROS production.
Journal ArticleDOI
Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3
Nathaniel Robichaud,S V del Rincon,Bonnie Huor,Tommy Alain,Luca A. Petruccelli,Jaclyn Hearnden,Christophe Goncalves,Stefan Grotegut,Charles Spruck,Luc Furic,Ola Larsson,William J. Muller,Wilson H. Miller,Nahum Sonenberg +13 more
TL;DR: It is shown that mice in which eukaryotic translation initiation factor 4E (eIF4E) cannot be phosphorylated are resistant to lung metastases in a mammary tumor model, and that cells isolated from these mice exhibit impaired invasion.
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Vorinostat Induces Reactive Oxygen Species and DNA Damage in Acute Myeloid Leukemia Cells
Luca A. Petruccelli,Daphné Dupéré-Richer,Filippa Pettersson,Helene Retrouvey,Sophia Skoulikas,Wilson H. Miller +5 more
TL;DR: It is found that pre-treatment with the antioxidant N-acetyl cysteine (NAC) reduces vorinostat-induced DNA double strand breaks, G2-M arrest and apoptosis in both AML cell lines and patient-derived blasts.
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Inhibition of DNA Methyltransferase Activates Tumor Necrosis Factor α–Induced Monocytic Differentiation in Acute Myeloid Leukemia Cells
Anna Laurenzana,Luca A. Petruccelli,Luca A. Petruccelli,Filippa Pettersson,Filippa Pettersson,Maria E. Figueroa,Ari Melnick,Albert S. Baldwin,Francesco Paoletti,Wilson H. Miller,Wilson H. Miller +10 more
TL;DR: The results support the concept of low doses of 5-AZA-dC acting in combination with other agents to target epigenetic changes that drive malignant growth in leukemic cells.
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Exposure to tungsten induces DNA damage and apoptosis in developing B lymphocytes.
TL;DR: Tungsten exposure has been linked to several leukemia clusters, including the well-publicized one in Fallon, Nevada, as well as Sierra Vista, Arizona and Elk Grove, California, which undoubtedly had multiple potential exposures, but the contribution of tungsten to the generation of leukemia is unknown.