J
Jaclyn Hearnden
Researcher at McGill University
Publications - 5
Citations - 491
Jaclyn Hearnden is an academic researcher from McGill University. The author has contributed to research in topics: EIF4E & Phosphorylation. The author has an hindex of 5, co-authored 5 publications receiving 379 citations.
Papers
More filters
Journal ArticleDOI
Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3
Nathaniel Robichaud,S V del Rincon,Bonnie Huor,Tommy Alain,Luca A. Petruccelli,Jaclyn Hearnden,Christophe Goncalves,Stefan Grotegut,Charles Spruck,Luc Furic,Ola Larsson,William J. Muller,Wilson H. Miller,Nahum Sonenberg +13 more
TL;DR: It is shown that mice in which eukaryotic translation initiation factor 4E (eIF4E) cannot be phosphorylated are resistant to lung metastases in a mammary tumor model, and that cells isolated from these mice exhibit impaired invasion.
Journal ArticleDOI
La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1)
Bruno D. Fonseca,Chadi Zakaria,Jian Jun Jia,Tyson E. Graber,Yuri V. Svitkin,Soroush Tahmasebi,Danielle Healy,Huy-Dung Hoang,Jacob Malte Jensen,Ilo T. Diao,Alexandre A. Lussier,Christopher Dajadian,Niranjan Padmanabhan,Walter Wang,Edna Matta-Camacho,Jaclyn Hearnden,Ewan M. Smith,Yoshinori Tsukumo,Akiko Yanagiya,Masahiro Morita,Emmanuel Petroulakis,Jose L. González,Greco Hernández,Tommy Alain,Christian Kroun Damgaard +24 more
TL;DR: It is reported that LARP1 functions as a key repressor of TOP mRNA translation downstream of mTORC1, and reducing LARP 1 protein levels by RNA interference attenuates the inhibitory effect of rapamycin, Torin 1, and amino acid deprivation on TOP mRNAtranslation.
Journal ArticleDOI
mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1.
Jian-Jun Jia,Roni M. Lahr,Michael T Solgaard,Bruno J Moraes,Roberta Pointet,An-Dao Yang,Giovanna Celucci,Tyson E. Graber,Huy-Dung Hoang,Marius R. Niklaus,Izabella A. Pena,Anne Kruse Hollensen,Ewan M. Smith,Malik Chaker-Margot,Leonie Anton,Christopher Dajadian,Mark Livingstone,Jaclyn Hearnden,Xu-Dong Wang,Yonghao Yu,Timm Maier,Christian Kroun Damgaard,Andrea J. Berman,Tommy Alain,Bruno D. Fonseca +24 more
TL;DR: In this article, the authors reveal that mTORC1 phosphorylates LARP1 in vitro and in vivo, activities that are efficiently inhibited by rapamycin and torin1.
Journal ArticleDOI
Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis.
Chadi Zakaria,Polen Sean,Huy-Dung Hoang,Louis-Phillipe Leroux,Margaret Watson,Samuel T Workenhe,Jaclyn Hearnden,Dana Pearl,Vinh Tai Truong,Nathaniel Robichaud,Akiko Yanagiya,Soroush Tahmasebi,Seyed Mehdi Jafarnejad,Jian-Jun Jia,Adrian Pelin,Jean-Simon Diallo,Fabrice Le Boeuf,John C. Bell,Karen L. Mossman,Tyson E. Graber,Maritza Jaramillo,Nahum Sonenberg,Tommy Alain +22 more
TL;DR: The data show that altered eIF4E/4E-BPs expression can act to promote HSV1-dICP0 infection under prolonged mTOR inhibition, and pharmacoviral combination of asTORi and HSV 1 can target cancer cells displaying dysregulated eIF 4E/ 4E- BPs axis.
Posted ContentDOI
LARP1 is a major phosphorylation substrate of mTORC1
Bruno D. Fonseca,Jian-Jun Jia,Anne Kruse Hollensen,Roberta Pointet,Huy-Dung Hoang,Marius R. Niklaus,Izabella A. Pena,Roni M. Lahr,Ewan M. Smith,Jaclyn Hearnden,Xu-Dong Wang,An-Dao Yang,Giovanna Celucci,Tyson E. Graber,Christopher Dajadian,Yonghao Yu,Christian Kroun Damgaard,Andrea J. Berman,Tommy Alain +18 more
TL;DR: This study examined the phosphorylation of a recently identified target of mTORC1: La-related protein 1 (LARP1), a member of the LARP superfamily, and revealed LARP1 as a major substrate of m TORC1.