Luca Castelli

TL;DR: In vitro, exogenous OPN decreased activation-induced T-cell death, which suggests that high OPN levels are involved in the apoptosis defect.

TL;DR: These data suggest the independent effect of a promoter (-156) and a 3'-untranslated region (+1239) SNP in SLE susceptibility and can speculate that these sequence variants create a predisposition to high production of OPN, and that this in turn may confer susceptibility to SLE.

TL;DR: In AA patients, OPN levels were higher than in AA controls and similar to those found in both non-AA patients and controls, which suggests a role of the activated immune response, and data suggest that OPN genotypes may influence MS development and progression due to their influence on OPN Levels.

TL;DR: Assessment of ICOS function in human naïve CD4+ T cells through an assessment of the effect of soluble forms of the ICOS and CD28 physiological ligands on activation driven by anti‐CD3 mAb suggests that ICOS favors differentiation of Th effector cells when cooperates with appropriate activation stimuli, whereas it supports differentiation of regulatory T cells when costimulatory signals are insufficient.

TL;DR: Human ICOS is a T cell costimulatory molecule supporting IL10 secretion and Activated T cells from healthy AA homozygotes expressed significantly less ICOS and secreted more IL10 than AC heterozygote, whereas AB heterozygotes displayed intermediate levels.