Luca Diamanti

TL;DR: The “ambivalent” behavior of SOD1 in ALS disease will be resolved and sporadic ALS patients will be classified according to a novel biological signature, i.e., SOD localization.

TL;DR: The role of environmental factors in ALS is analyzed: heavy metals, electromagnetic fields and electric shocks, pesticides, β-N-methylamino-L-alanine, physical activity and the controversial role of sports.

TL;DR: MVs and EXOs size were increased in ALS patients compared to controls and MVs of ALS patients were enriched with toxic proteins compared to CTRLs, which may suggest that MVs can transport toxic proteins and might play a role in prion-like propagation of ALS disease.

TL;DR: A whole transcriptome RNA-seq analysis was performed to investigate the regulation of non-coding and coding RNAs in Sporadic ALS patients, mutated ALS patients and matched controls in Peripheral Blood Mononuclear Cells, offering starting points for new investigations about pathogenic mechanism involved in ALS disease.

TL;DR: The data suggest that CCPD has heterogeneous features and shows frequent post-infectious onset, primary peripheral nervous system or central nervous system involvement, a monophasic or chronic disease course, inadequate response to treatments, and a generally poor outcome.