Matteo Bordoni

TL;DR: The “ambivalent” behavior of SOD1 in ALS disease will be resolved and sporadic ALS patients will be classified according to a novel biological signature, i.e., SOD localization.

TL;DR: A whole transcriptome RNA-seq analysis was performed to investigate the regulation of non-coding and coding RNAs in Sporadic ALS patients, mutated ALS patients and matched controls in Peripheral Blood Mononuclear Cells, offering starting points for new investigations about pathogenic mechanism involved in ALS disease.

TL;DR: The role of immune system alterations in frailty, the role of genetic factors inFrailty onset and the impact of diet on inflammation and, in turn, on frailty are discussed.

TL;DR: The conductive guidelines promote the cell differentiation, regardless of using differentiation factors, and the electrical conductivity of the 3D printed scaffolds could be tuned by calcium–induced crosslinking of alginate, which plays a significant role on neural cell differentiation.

TL;DR: 3D bioprinting allows to control the distribution of cells such as neurons, leading to the creation of a realistic in vitro model, and the maintenance of the printed shape is evaluated, opening the possibility to obtain a reliable in vitro neural tissue combining 3D biopsying and iPSCs technology.