L
Luca Parrillo
Researcher at University of Naples Federico II
Publications - 24
Citations - 1365
Luca Parrillo is an academic researcher from University of Naples Federico II. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 14, co-authored 21 publications receiving 780 citations. Previous affiliations of Luca Parrillo include National Research Council.
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Journal ArticleDOI
Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications
Michele Longo,Federica Zatterale,Federica Zatterale,Jamal Naderi,Jamal Naderi,Luca Parrillo,Luca Parrillo,Pietro Formisano,Pietro Formisano,Gregory Alexander Raciti,Gregory Alexander Raciti,Francesco Beguinot,Francesco Beguinot,Claudia Miele,Claudia Miele +14 more
TL;DR: A better understanding of the mechanisms regulating adipose tissue expansion in obesity is required for the development of future therapeutic approaches in obesity-associated metabolic complications.
Journal ArticleDOI
Revising the embryonic origin of thyroid C cells in mice and humans
Ellen Johansson,Louise Andersson,Jessica Örnros,Therese Carlsson,Camilla Ingeson-Carlsson,Shawn Liang,Jakob Dahlberg,Svante Jansson,Luca Parrillo,Pietro Zoppoli,Guillermo Barila,Daniel L. Altschuler,Daniela Padula,Heiko Lickert,Henrik Fagman,Mikael Nilsson +15 more
TL;DR: With lineage tracing, this work provides direct evidence that Sox17+ anterior endoderm is the only source of differentiated C cells and their progenitors in mice, disproving the current concept of a neural crest origin of thyroid neuroendocrine cells and revise mammalian C cell ontogeny.
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Gene expression profiling at early organogenesis reveals both common and diverse mechanisms in foregut patterning.
Henrik Fagman,Elena Amendola,Luca Parrillo,Pietro Zoppoli,Pina Marotta,Marzia Scarfò,Pasquale De Luca,Denise P. Carvalho,Michele Ceccarelli,Mario De Felice,Roberto Di Lauro +10 more
TL;DR: A regulatory pathway involving the anti-apoptotic gene Bcl2 that controls cell survival in early thyroid development is described and described as an initial step in this direction to discover organ specific as well as common developmental mechanisms.
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Msx1 and tgf-β3 are novel target genes functionally regulated by foxe1
TL;DR: It is shown that all the known forkhead-domain mutations, but not the polyalanine-stretch polymorphisms, affect the FOXE1 ability to bind to and transactivate MSX1 and TGF-β3 promoters.
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Understanding type 2 diabetes: from genetics to epigenetics
Gregory Alexander Raciti,Michele Longo,Luca Parrillo,Marco Ciccarelli,Paola Mirra,Paola Ungaro,Pietro Formisano,Claudia Miele,Francesco Beguinot +8 more
TL;DR: Recent evidence from the literature supporting the immediate need for further investigation to uncover the power of epigenetics in the prediction, prevention and treatment of type 2 diabetes is discussed.