L
Lucas Michel-Todó
Researcher at University of Barcelona
Publications - 9
Citations - 149
Lucas Michel-Todó is an academic researcher from University of Barcelona. The author has contributed to research in topics: Heterochromatin & Epitope. The author has an hindex of 3, co-authored 8 publications receiving 61 citations.
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Journal ArticleDOI
Conditional expression of PfAP2-G for controlled massive sexual conversion in Plasmodium falciparum.
Oriol Llorà-Batlle,Lucas Michel-Todó,Kathrin Witmer,Haruka Toda,Carmen Fernandez-Becerra,Jake Baum,Alfred Cortés +6 more
TL;DR: A system for controlled sexual conversion in the human malaria parasite Plasmodium falciparum, based on conditional expression of the PfAP2-G transcription factor is described, enabling the characterization of committed and early sexual stages without further purification.
Journal ArticleDOI
In silico Design of an Epitope-Based Vaccine Ensemble for Chagas Disease.
Lucas Michel-Todó,Pedro A. Reche,Pascal Bigey,María-Jesús Pinazo,Joaquim Gascon,Julio Alonso-Padilla +5 more
TL;DR: A set of epitopes that have <70% identity to human or human microbiome protein sequences and represent the basis toward the development of an epitope-based vaccine against T. cruzi are prioritized by means of a computer-aided strategy.
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A heat-shock response regulated by the PfAP2-HS transcription factor protects human malaria parasites from febrile temperatures.
Elisabet Tintó-Font,Lucas Michel-Todó,Timothy J. Russell,Núria Casas-Vila,David J. Conway,Zbynek Bozdech,Manuel Llinás,Alfred Cortés +7 more
TL;DR: In this article, the authors showed that PfAP2-HS, a transcription factor in the ApiAP2 family, regulates the protective heat-shock response in Plasmodium falciparum.
Journal ArticleDOI
Design of an Epitope-Based Vaccine Ensemble for Animal Trypanosomiasis by Computational Methods.
Lucas Michel-Todó,Pascal Bigey,Pedro A. Reche,María-Jesús Pinazo,Joaquim Gascon,Julio Alonso-Padilla +5 more
TL;DR: In this paper, the authors proposed a vaccine strategy based on multiple epitopes from multiple antigens to counteract the parasites' biological complexity, which can represent a major breakthrough towards the management and control of the disease.
Journal ArticleDOI
Expression Patterns of Plasmodium falciparum Clonally Variant Genes at the Onset of a Blood Infection in Malaria-Naive Humans.
Anastasia K. Pickford,Lucas Michel-Todó,Florian Dupuy,Alfredo Mayor,Pedro L. Alonso,Catherine Lavazec,Alfred Cortés +6 more
TL;DR: In this paper, the authors provided a detailed characterization of the complete P. falciparum transcriptome across the full intraerythrocytic development cycle (IDC) at the onset of a blood infection in malaria-naive human volunteers.